Literature
Peer-reviewed publications featuring metabolomics
Modulating gut microbiota with enterosynes could control type 2 diabetes
Modulation of gut microbiota with prebiotic Fructooligosaccharides (FOS) led to discovery of two novel enterosynes (12-HETE and enkephalin), with potential to control type 2 diabetes
Commentary – A current view on steroid hormones
Although they are only present in low concentration in our bodies, steroid hormones play a crucial role in a variety of biological processes. This article reflects recent studies on the topic.
Giardia lamblia alters bile acid secretion in mice
A neonatal mouse model demonstrated that G. lamblia infection altered the composition of the gut microbiome and enhanced bile acid secretion and deconjugation.
Blood-based score objectively captures dietary patterns
A blood-based predictive metabolomics score provides a tool linking dietary patterns to risk of diabetes that can be used to objectively assess dietary intake.
Microbiome instability and host metabolic dysfunctions
Plasma metabolome and microbiota profiles from the SHIP cohort link microbiome instability to liver steatosis, diabetes mellitus, and pancreatic dysfunction
Circulating metabolites shed light on mechanism of action
The changes in circulating metabolites induced by a multi-AGC kinase inhibitor in mice and patients may contribute to better understand its mechanism of action.
Prediction of cancer survival rate with metabolomics
Metabolomics can be combined with clinical data for the prediction of patient survival after anti-tumor treatment.
Metabolomic profiling and the prediction of 90-day mortality
Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)
Kynurenine metabolites mediate neuromuscular dysfunction
Accumulation of neurotoxic kynurenine metabolites with aging represents the mechanism of neuromuscular defects linking chronic inflammation to physical frailty.
Machine learning for ALS progression biomarker discovery
How to combine targeted metabolomics and machine learning algorithms to identify biomarkers associated with ALS disease progression.
Bile acids and newborn’s gut microbiota maturation
The maturation of the newborn´s microbiome is critically dependent on bile acids from liver and can be manipulated by administration of bile acids in mice.
Circulating metabolites predict coronary heart disease risk
Serum metabolites were associated with risk of coronary heart disease in a population-based cohort, with a comparable strength to classic risk factors.
Metabolite of the month – Carnitine
Metabolite of the month is your sneak peek into the world of metabolomics. This month we look at carnitine #loveyourmetabolites
Elevated serum bile acid levels contribute to NASH-HCC
Higher serum bile acid levels and an altered gut microbiome contribute to fibrogenesis, liver injury, and tumorigenesis in cirrhotic and noncirrhotic NASH-HCC.
Mitochondria’s role in clinical depression
What does brain activity look like after anti-depressant treatment and what is the basis for prescribing serotonin re-uptake inhibitors in the first place?
Gut microbiota and statins
Metabolomics and 16S rRNA profiling uncover the crosstalk between gut microbiota and statins efficacy that can hide behind inter-individual variability.
Is Alzheimer’s a metabolic disease?
Alzheimer’s disease (AD) has many facets. Metabolomics supports Alzheimer’s early diagnosis and research on the treatment of AD.
Lipidomics in cardiac patients after the Fontan procedure
Lipidomics reveals long-term effects of palliative surgeries in Fontan patients after cardiac function is restored.
Therapy response monitoring in infectious diseases
Monitoring COVID-19 patient’s pathophysiology using metabolomics can lead to early detection of therapy response, opening an avenue to precision medicine.
Metabolomics and COVID-19
Monitoring COVID-19 patient’s pathophysiology might lead to early detection of therapy response, opening an avenue to precision medicine. Metabolomics is a tool to support these efforts.
Best practices for feces metabolomics
biocrates enables reproducible quantitative metabolomics in fecal samples. Understand the challenges associated with this matrix.
The metabolic cost of a marathon: fitness matters
Targeted metabolomics reveals differences in metabolic profiles between top athletes and amateur runners days after running a marathon.
Amino acids aid in diagnosis of tuberculosis infection
Amino acids were identified as serum biomarkers for the diagnosis of patients with active tuberculosis infection in a targeted metabolomics study.
Metabolomics in Multiple Sclerosis
Finding a test for different types of multiple sclerosis has been proven to be difficult. Metabolomics as a solution is explored in the study portrayed here.
Webinar report – Metabolomics, Nutrition, Microbiome
“Metabolomics – between Nutrition, Microbiome, and Disease” demonstrates that metabolomics is a powerful tool to study host-microbiota-diet interactions
What urine can tell about the metabolome
Biocrates enables reproducible quantitative metabolomics in urine samples, a biofluid of choice for biomarker discovery in medicine and biology.
Obesity and the microbiome
Metagenomics, metaproteomics and metabolomics create an exciting mix of approaches to understand systematic changes in an organism after external perturbations.
Does metabolic syndrome manifest itself differently?
An international team of scientists applied targeted metabolomics to deepen the mechanistic understanding of metabolic syndrome and its regional specificities.
Which metabolites tell your diet?
Uncovering the mechanism linking the Mediterranean diet with reduced risk for cardiometabolic diseases using targeted metabolomics.
Could probiotics replace antibiotics?
How can the use of antibiotics in animal farming be reduced? Probiotics might be a solution.
Make sure your drug fits to your cancer
The response of cancer cells to checkpoint inhibition therapy can be predicted using metabolomics.
Arginine metabolism: Targeted metabolomics and biochemical pathways
Metabolic syndrome is associated with changes in amino acid metabolites. The korean genome and epidemiology study finds involvement of arginase activity
Feature: MetaboINDICATOR and biogenic amines
Targeted metabolomics support the study of animal health. The diet of cows (high vs low energy) has influence on the metabolite levels of the offspring.
Gender differences in brain – revealed by metabolomics
Female and male mice may think differently. Targeted metabolomics reveals differences in brain chemistry between the two which might account for behavioral differences.
A metabolic profile of all-cause mortality risk
To predicting life expectancy standardized and reproducible scientific methods are needed. Metabolomics is one way to approach this question.
Betaine for a healthy life and brain?
Betaine supplementation has a profound effect on phospholipid metabolism. Its effect on brain and liver health can be studied using targeted metabolomics.
Serine – nonessential for you, but essential for cancer
One of the widely accepted hallmarks of cancer is metabolic deregulation. By integrating transcriptome, proteome, and metabolome analysis insights on cancer can be gained.
Microbiome and cognition in Alzheimer´s disease
Due to the fact that in Alzheimers bile acids as well as the microbiome play a key role, standardized metabolomics is particularly well adapted to study Alzheimers.
Metabolomics can indicate favorable response to microbiota transfer
The study of the microbiome is a vital part of personalized medicine. Targeted metabolomics supports patient stratification in Clostridiodes patients.
Metabolomics of acute heart failure
Acute and chronic heart failure can be studied using metabolomics. The metabolic phenotype (especially lipids/ amino acids) rapidly changes upon these condition
Nutrition might still improve your health
The health benefits of Omega 3 fatty acids are well documented. Metabolomics studies can help to elucidate the beneficial effects of nutrition on body and mind.