The metabolite of this month is cholic acid, of the the bile acid class. Notorious for their role in digestion, they are also powerful regulators of metabolism.
Metabolite of the month – Cholic acid
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Neurology
Kynurenine metabolites mediate neuromuscular dysfunction
Accumulation of neurotoxic kynurenine metabolites with aging represents the mechanism of neuromuscular defects linking chronic inflammation to physical frailty.
Metabolite of the month – Kynurenine
The metabolite of this month focuses on kynurenine, a tryptophan-derived metabolite at the crossroads between neurology, immunology and cancer.
Machine learning for ALS progression biomarker discovery
How to combine targeted metabolomics and machine learning algorithms to identify biomarkers associated with ALS disease progression.
Mitochondria’s role in clinical depression
What does brain activity look like after anti-depressant treatment and what is the basis for prescribing serotonin re-uptake inhibitors in the first place?
Is Alzheimer’s a metabolic disease?
Alzheimer’s disease (AD) has many facets. Metabolomics supports Alzheimer’s early diagnosis and research on the treatment of AD.
Metabolomics in Multiple Sclerosis
Finding a test for different types of multiple sclerosis has been proven to be difficult. Metabolomics as a solution is explored in the study portrayed here.
Gender differences in brain – revealed by metabolomics
Female and male mice may think differently. Targeted metabolomics reveals differences in brain chemistry between the two which might account for behavioral differences.
Betaine for a healthy life and brain?
Betaine supplementation has a profound effect on phospholipid metabolism. Its effect on brain and liver health can be studied using targeted metabolomics.
Microbiome and cognition in Alzheimer´s disease
Due to the fact that in Alzheimers bile acids as well as the microbiome play a key role, standardized metabolomics is particularly well adapted to study Alzheimers.