Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at phosphatidylcholines, a class of lipids involved in much more than membrane composition.
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Infectiology is the study of infectious diseases. It is a branch of medicine that deals with the diagnosis, treatment, and prevention of infectious diseases. These diseases can be caused by viruses, bacteria, fungi, or parasites. They can affect any part of the body, including the skin, respiratory system, gastrointestinal system, or central nervous system.
Lipid biomarkers improve diagnosis of bacterial meningitis
Free phosphatidylcholines in cerebrospinal fluid are highly promising biomarkers for an improved differential diagnosis of bacterial meningitis.
Multi-omics reveals new insights into chronic malarias
Host-parasite interactions in chronic and acute malaria were characterized by metabolomics and transcriptomics in macaques and humans.
Metabolomics reveals link between adipose tissue and severe COVID-19
A lipid signature is associated with disease severity and inflammatory status in patients with COVID-19.
Giardia lamblia alters bile acid secretion in mice
A neonatal mouse model demonstrated that G. lamblia infection altered the composition of the gut microbiome and enhanced bile acid secretion and deconjugation.
Metabolite of the month – Arachidonic acid
The metabolite of this month is arachidonic acid, a polyunsaturated fatty acid at the crossroads between inflammation, athlete training and the latest COVID-19 research.
Metabolomic profiling and the prediction of 90-day mortality
Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)
COVID-19 – Metabolomics prediction of long-term outcome
Those who recover from COVID-19, especially after severe cases, have experienced a great deal of pain and discomfort. However, because of potential multi-organ injuries that more closely resemble the situation after sepsis rather than recovery from an Influenza virus infection, COVID-19 survivors often experience long-term consequences of the infection.
COVID-19 Utility of animal models
The global impact of the COVID-19 pandemic has prompted collaborative research efforts across the world. Thus far, the bulk of these efforts have been geared towards vaccine development and discovery of therapeutic strategies that mitigate disease severity.
Metabolomics and response to SARS-CoV-2 vaccination
While vaccine development has been faster than for any previous emerging infectious disease, the next big challenge will be the logistics of producing and distributing hundreds of millions of doses.
Metabolic interaction of COVID-19 and metabolic diseases
It is well established that within the context of infectious diseases, both host and pathogen impact each other’s metabolism. Viral diseases, such as COVID-19, perfectly exemplify this, as the virus hijacks host cells in order to survive and replicate.
Amino acids aid in diagnosis of tuberculosis infection
Amino acids were identified as serum biomarkers for the diagnosis of patients with active tuberculosis infection in a targeted metabolomics study.