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Nicotinic acid has evolved from a pellagra-curing vitamin to a context‑dependent metabolic modulator, linking vitamin B₃ biology with NAD⁺ metabolism, lipid regulation, immunity, and host–microbiome interactions. Its history and mechanisms exemplify how nutritional discoveries have shaped modern precision approaches to cardiometabolic and inflammatory disease.
Read in this article about how exposomics and metabolomics together provide a powerful, complementary framework for advancing 5P medicine by linking environmental exposures with measurable metabolic phenotypes.
The metabolite of this month is UDCA, a secondary bile acid metabolite which plays a significant role in hepatology, neurology, and gastrointestinal research.
The metabolite of this month is spermidine, a biogenic amine with applications in cancer, neurology and hair research.
Combining genome-wide association studies (GWAS) with metabolomics and Mendelian randomization is transforming precision medicine by uncovering causal links between genetic variants and clinical outcomes, rather than just correlations.