As one of the metabolites responsible for the smell of conifers, alpha-pinene is a fitting choice for our festive Metabolite of the month.
Alpha-pinene – Metabolite of the month
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Pharmacology
Treatment of non-alcoholic fatty liver disease (NAFLD) as a chemopreventive strategy for other chronic disease: a metabolomics perspective
NAFLD is a key player in other chronic diseases – both as a prevalent comorbidity and a contributing factor. Does this mean that treating NAFLD could prevent those conditions?
Metabolomics – (not) a game changer in toxicology?
Why is metabolomics a game-changer in toxicology? We think so, but why are toxicologists split on this question?
Cell culture metabolomics – The shortcut to drug development
Cell culture metabolomics is an excellent tool to decrease drug development costs while increasing speed and success rate. Its applicability has been proven in numerous studies.
Adverse effects in immunotherapy
Only 20–30 % of patients experience a long-term benefit from immunotherapy, but the high rate of adverse events in immunotherapies is also a matter of intense research and scientific debate
Therapy resistance: could metabolomic biomarkers remove this major roadblock to successful pharmaceutical research and development programs?
Pharmaceutical therapies have created huge benefits for society in expanding healthy life span
Are effects of antibiotics reflected in the metabolome?
Antibiotics influence the gut microbiome and the plasma or fecal metabolome depending on the class of antibiotics and the gut bacterial composition.
Metabolic effects of anti-TNF α therapy
Anti-TNF α therapy in Crohn´s Disease improves liver steatosis through changes in gut bacteria and triglycerides.
Pharmacometabolomics provides biomarkers for precision medicine
A combination of various technologies in pharmacometabolomics enables biomarker discovery for prediction of drug responses of individual patients.
Distinct metabolic alterations in cancer- and chemotherapy-induced cachexia
Cancer in comparison to chemotherapy cause distinct metabolic perturbations, which both lead to the development and progression of cachexia characterized by extreme weight loss and muscle wasting.
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