The maturation of the newborn´s microbiome is critically dependent on bile acids from liver and can be manipulated by administration of bile acids in mice.
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Higher serum bile acid levels and an altered gut microbiome contribute to fibrogenesis, liver injury, and tumorigenesis in cirrhotic and noncirrhotic NASH-HCC.
Betaine supplementation has a profound effect on phospholipid metabolism. Its effect on brain and liver health can be studied using targeted metabolomics.