Metabolomic Phenotyping Services
Expert support from study design to actionable results
Our Metabolomic Phenotyping Services enable a quality-controlled, highly reproducible, quantitative analysis across the metabolite spectrum. Our expert services offer full support in every step of your project, including sample preparation, shipment, project management, statistical analysis, and biomedical data interpretation.
Short turn-around times
- High-quality results typically < 12 weeks after sample receipt
- Expert analysis in specialized routine laboratory
- Experience with (pre-analytical) sample handling
Targeted & quantitative metabolomics at your service
Comprehensive analytical portfolio
Our Metabolomic Phenotyping Services allow for customized selection of assays which cover a wide range of physiological processes
|Approach||Assay Name||Number & Class of Metabolites|
|Kit-based assays||MxP® Quant 500 kit||Up to 107 small molecules & 523 lipids|
|AbsoluteIDQ® p400 HR kit||Up to 43 small molecules & 365 lipids|
|AbsoluteIDQ® p180 kit||Up to 43 small molecules & 145 lipids|
|AbsoluteIDQ® Stero17 kit||Up to 17 steroid hormones|
|Biocrates® Bile Acids kit||Up to 20 bile acids|
|Eicosanoid assay||Up to 17 eicosanoids|
|Fatty acid assay (total / free)||Up to 31 / 32 fatty acids|
|Lipid assay||Up to 326 lipids|
|Oxysterol assay||Up to 18 free (oxy-) sterols|
|Energy metabolism assay||Up to 21 energy metabolism intermediates|
|NEW Tryptophan metabolism assay||Up to 17 metabolites from the tryptophan pathway|
For more information on the NEW Tryptophan metabolism assay, please click here.
- Amine oxides
- Amino acids
- Amino acid related
- Bile acids
- Biogenic amines
- Carbohydrates and related
- Carboxylic acids
- Energy metabolism intermediates
- Fatty acids
- Hormones and related
- Indoles and derivatives
- Nucleobases and related
- Vitamins and cofactors
- Cholesteryl esters
- Free (oxy-)sterols
Applicability to species and biological matrices
Sample preparation methods can strongly influence the yield of extraction of metabolites and the overall sensitivity of metabolomic experiments. We are experienced in handling and preparing samples from a broad range of biological matrices from various species.
Below is a non-exhaustive list of the species / matrices processed over the years. To check on the current recommendations for your species or matrix of interest, please contact us.
|Species||Human, mouse, rat, chicken, pig, sheep, cow, dog, primate, guinea pig, hamster, fish, C. elegans, E. coli, P. pastoris|
|Matrix||Body Fluids||Plasma, serum, urine, whole blood, Interstitial fluid ("blister liquid") , saliva, cerebrospinal fluid (CSF), bronchoalveolar lavage fluid (BALF), milk|
|Tissue||Liver, kidney, brain, lung, prostate, ovary, breast, colon, pancreas, muscle, skin|
|Cell Culture||CHO cells, cultivated cancer cells, inclusion bodies, media and supplements (soy and yeast hydrolysates), neuronal cells|
|Others||Feces, dried blood/plasma spots, cecal content|
Biostatistics & data interpretation
Confident decision making based on metabolomics requires comprehensive statistical analysis and informed interpretation of the analytical data.
Biocrates generates for you a customized data report, delivering actionable results derived from robust and reproducible metabolomic data. With our profound scientific expertise in biostatistics and metabolomics we offer three reporting options:
In metabolomics, an elaborate study design is crucial to obtain meaningful, actionable results.
Therefore, our tailor-made support services include project management and guidance in:
- Selection of scientific question & most suitable metabolomic assay(s)
- Study design & feasibility
- Sample handling: collection, processing, storage, shipment
We offer guidance on best practices to handle your samples for measurement with our Services. For specific recommendations on blood sample preparation for targeted metabolomics, see our Sample Preparation Guidelines. For recommendations on how to collect and handle tissue, cell culture samples and more, please contact us.