Quantitative metabolomics database

QMDB – Quantitative metabolomics database

“What is the normal concentration range for this metabolite?” This question is frequently asked in many comparative metabolomics studies. Since every individual is different and the metabolome varies due to external and internal factors, “normal” is very hard to define. To address this question, biocrates created the first quantitative and standardized metabolite database.

QMDB advances metabolomics research

What is the normal concentration range for this metabolite?” This question is frequently asked in many comparative metabolomics studies. Since every individual is different and the metabolome varies due to external and internal factors, “normal” is very hard to define. To address this question, biocrates created the first quantitative and standardized metabolite database

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The QMDB combines sample metadata with quantitative reference ranges based on standardized biocrates technology. It provides insights into the metabolomic differences among ethnicities, sex, and lifestyles. Whether saving valuable resources by reducing the need for additional control samples, or confirming metabolomics hypotheses, the QMDB resolves questions about normal metabolite ranges and advances metabolomics research.

Application Note
Validation and application of the Quantitative Metabolomics Database (QMDB)

How does the QMDB support experimental metabolomics?

Normal ranges for metabolomics

Access ranges for over 620 metabolites for insights into metabolomes of healthy subgroups
Characterize own control groups by comparing them to the QMDB and identify outliers

Reference control groups

Include reference ranges in data analysis and interpretation
Achieve greater insight without the need for additional controls

In silico studies

Identify novel metabolic signatures within QMDB subgroups
Formulate and test metabolic hypotheses before starting experiments

Become part of a data network

Compare own results with data generated in the community
Contribute to the growing database and benefit together with others

QMDB offers flexible selection criteria

The QMDB contains metabolite concentration ranges detected in human plasma samples from healthy individuals. Included subjects were undiagnosed of any diseases and therefore are considered a healthy reference. Many filter options are available (including demographics, BMI, lifestyle choices, etc.) to precisely match your reference group of interest.

QMDB is based on MxP® Quant 500 and AbsoluteIDQ® p180 assay data.

Filter options

Results

Gordian Adam, PhD

Senior Scientist | Team Lead Data Interpretation

biocrates life sciences, Innsbruck, Austria

This virtual event discusses

Key features and benefits of using QMDB
Demographics of the study population
Validation procedures for the database
Case study for the QMDB

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Opinions

“One challenge we face in clinical research is the limitation of the number of precious samples and the unique nature of each sample. It can be difficult to acquire matched controls for every study. We tested the QMDB and the various filter options matched well to study groups and the results aligned with our control groups. Reassurance by the QMDB helped us to verify that our results were within normal ranges and provide further power to our study.”

Teodoro Bottiglieri, PhD

Director of Research, Center of Metabolomics; Baylor Scott & White Research Institute

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