Metabolomics in Multiple Sclerosis

by | Apr 14, 2020 | Neurology, Literature

Multi-Platform Characterization of Cerebrospinal Fluid and Serum Metabolome of Patients Affected by Relapsing–Remitting and Primary Progressive Multiple Sclerosis

How can a disease be diagnosed, let alone be treated, when there are  no identified common phenotype is manifested in  several stages of progression? Compounding this reality, Multiple Sclerosis (MS) patients are often diagnosed at later stages of the disease.

Murgia et al. conducted a metabolomics study on serum and cerebrospinal fluid of patients suffering from MS. There are three types of MS (relapsing (RRMS), primary progressive (PPMS), and secondary progressive (SPMS)).  Patients from the first two types were compared in this study.

Changes in metabolic profiles between the patient groups were  found to be of  high selectivity and specificity, which creates hope for a better suited MS future laboratory test. Additionally, metabolomics can also  provide insights into the biology of the disease as the authors point out in the discussion of the study.

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Federica Murgia, Lorena Lorefice, Simone Poddighe, Giuseppe Fenu, Maria Antonietta Secci, Maria Giovanna Marrosu, Eleonora Cocco, Luigi Atzori: Multi-Platform Characterization of Cerebrospinal Fluid and Serum Metabolome of Patients Affected by Relapsing–Remitting and Primary Progressive Multiple Sclerosis. J. Clin. Med 2020 https://doi.org/10.3390/jcm9030863

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