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Metabolites are essential for life. They are the products of the chemical processes that occur in the body and are necessary for the body to function. Metabolites can be used as biomarkers to diagnose disease and to assess treatment efficacy.
In this blog, we’ll take a closer look at one specific metabolite. Topics of discussion include the biosynthesis and degradation in a broader health context, and the effects of dysregulation in disease.
Cyclic adenosine monophosphate (cAMP) is a universal second messenger which translates extracellular cues into cellular responses regulating metabolism, gene expression, neurobiology, and immunity. Dysregulated cAMP signaling contributes to cancer, inflammation, and neurological disorders, making it a key target in precision medicine.
Bilirubin reduces oxidative stress, supports liver and cardiovascular functions, and protects against inflammation-related health conditions.
Itaconic acid shapes immune responses, affects the gut microbiome, and may influence cardiovascular, neurological, metabolic, and cancer outcomes.
Methylmalonic acid (MMA) is a key biomarker of vitamin B12 deficiency and plays a central role in energy metabolism.
The metabolite of this month is UDCA, a secondary bile acid metabolite which plays a significant role in hepatology, neurology, and gastrointestinal research.