Pharma

Epidemiology and biobanks

Decentralized metabolomics for the future of population health

Applying metabolomics to large, population-based cohorts requires three things:

  • comprehensive quantitative coverage of metabolites (for useful insights)
  • scalable technology (for easy implementation)
  • proven reproducibility (for comparison with other studies).

 

biocrates’ kit technology brings all three to scientists with large sample sets and biobank managers looking for new ways to characterize their samples. How can we support you?

Global community

Large studies already applying quantitative metabolomics

FAIR compliance

Solutions to guarantee your data ownership and collaboration

Metabolomics

Decentralized technology to support population-based studies

Pan-cohort event

Connecting scientists to shape the future of research and health

Connecting science globally

In the last decade, the field of metabolomics has been growing at an exponential rate, with scientists coming together to build a global network of population-based studies. This offers the scientific community an enormous opportunity to pool data for meta-analysis and further collaboration. Absolute quantification of metabolites with biocrates technology supports this, by making it easier to compare, exchange and integrate omics data between studies.

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Prof. Dr. Anette Peters
Metabolomics – From genetical to environmental influences

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Prof. Dr. Claudia Langenberg
Cross-platform genetic discovery of small molecule products of metabolism and clinical outcomes

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Prof. Dr. Seizo Koshiba
Metabolomics in the Tohoku Medical Megabank Cohort Project

Hundreds of thousands of samples in large epidemiological cohorts have been measured with biocrates technology, resulting in hundreds of publications. Please contact us for specific questions or for a comprehensive publication list.

To leverage your study and expedite insights on a global scale, build on our growing certified laboratory network or utilize innovative resources such as our Quantitative metabolomics database (QMDB).

FAIR data — biocrates democratizes metabolomics

In 2016, the “FAIR Guiding Principles for scientific data management and stewardship” were published in the journal Scientific Data. These guidelines aim to “improve the Findability, Accessibility, Interoperability, and Reuse of digital assets.” To meet the requirements of FAIR compliance, metabolomic data must fulfil the following criteria

Findable | Data need to be uploadable to data repositories

Accessible | The repository should be visible for the scientific community and publicly available

Interoperable | Uploaded data require a harmonized format and common units to enable shared data from different sources

Reusable | Data must be comparable, with long-term validity, independent of time

biocrates is committed to facilitating measurement of large numbers of samples with scientific and economic excellence. Our technology connects your results to other population-based studies globally, leveraging metabolite coverage and quantification of data with clinical relevance. All biocrates methods are standardized and quality controlled – data are quantifiable, reproducible and enable FAIR compliance.

Metabolomics in population-based studies

Metabolomics generates a wealth of information about the current state of health of individuals and groups. In contrast with techniques such as genomics, metabolomics provides a real-time snapshot of health and disease at the molecular level. The metabolome is dynamic and constantly changing, creating technical challenges which need to be taken into account during experimental planning, selection, handling and storage of samples, and in data analysis and interpretation.

In larger, multi-center studies, the following technological requirements are needed to make the studies successful

1. Comprehensive | Extensive coverage of dozens of biologically relevant pathways

2. Reproducible | Data based on robust analytical performance

3. Sustainable | Pooling of longitudinal and independent datasets for re-analysis in different contexts

4. Accessible | Broadly established technology

5. Scalable | Cost-efficient and timely analysis of tens of thousands of samples, ideally over multiple labs, locations and countries

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Prof. Dr. Jerzy Adamski
Study design for metabolomics research: challenges in biomedicine

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Prof. Dr. David Wishart
Why targeted metabolomics is essential for population health

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Prof. Dr. Augustin Scalbert
The exposome and cancer risk in the EPIC cohort – Results from recent metabolomics studies

Proven excellence by international ring trials

The superior lab-to-lab comparability of biocrates kits enables data integration from multiple laboratories — a key requirement for a scalable, decentralized global standard metabolomics solution. The technical excellence and global analytical reproducibility of biocrates kits have been proven in international ring trials, such as the MxP® Quant 500 ring trial. This included 14 participating laboratories from North America, Europe and Asia and demonstrated high reproducibility and sensitivity with excellent precision. The publication is currently under peer review.

2nd Pan-cohort studies –
The future of population health event

October 12, 2022
This meeting connected 3 continents in over 22 h of continuous livestream. Live events took place in Munich (Germany) and Boston (USA). Speakers from 20 countries and participants from more than 40 countries made this meeting truely international. 

Speakers and recorded livetalks
Abstract book
Summary article on the event (by Stefan Ledinger)

Watch all talks

population health

2nd Pan-cohort studies event

1st Pan-cohort studies –
The future of population health event

February 02, 2021
Fully virtual at the time of the pandemic, this event with 8 Speakers focussed on metabolomics as a core technology of future population health studies and the visions that need to be generated to make this happen. FAIR data treatment and connecting databases were discussed to make metabolomics data accessible and Speakers building this infrastructure had a priorized voice in this meeting.

Watch recordings on Youtube
Abstract book

Summary and abstract book

biocrates cohort virtual

1st Pan-cohort studies event

Connecting science globally

It is our vision to connect scientists globally to tackle the challenges modern medicine faces such as chronic diseases, ethnic underrepresentation, and cross-omics studies. Huge sample sets lie dormant and need to find the means to be explored. The Omics era with vast computational means opens new perspectives on data and on insights to be gained from datasets. Integration of different technologies makes collaboration more necessary.

Get in touch

biocrates life sciences ag
Eduard-Bodem-Gasse 8
6020 Innsbruck | AUSTRIA
Phone +43 512 579823
Fax +43 512 579823-329

biocrates inc.
26895 Aliso Creek Rd Ste B-426
Aliso Viejo, CA 92656-5301
Phone +1 774 424 8150
Operating hours: Mo – Fr | 9 am – 7 pm (EST)