Immunometabolism is an important component to the pathophysiology of inflammatory bowel diseases and thus may serve the purpose of contributing to better and more personalized therapy decisions. While several metabolic pathways contribute, the talk puts special emphasis on the metabolism of the essential amino acid tryptophan.
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Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment. Less than half of all patients respond to the primary treatment for PDAC, chemotherapy, and genetic alterations alone cannot explain this. Using shotgun metagenomic sequencing and metabolomic screening, we show that the microbiota-derived tryptophan metabolite indole-3-acetic acid (3-IAA) is enriched in patients who respond to treatment.
Metabolomics can be used to develop tools to help guide therapy decisions in multiple ways, e.g. predict whether a drug will be effective, choose the best course of therapy, or monitor therapies along the patient journey.
With the second edition of this cohort event Pan-cohort studies – The future of population health- we are looking forward to expand into the physical spaces and stretch the scope beyond metabolomics.
During this webinar you can learn about WebIDQ, the next evolution of biocrates’ metabolomics workflow management and data processing software. With an intuitive user interface, WebIDQ guides users from sample registration through quantification and reporting.
During this webinar you can learn the benefits and possibilites of using the biocrates Quantitative metabolomics database (QMDB)
During this webinar you can learn how microbiota impact the gut-immune axis through short- and medium-chain fatty acids
Depression has an impact on nitric oxide synthesis, urea cycle, inflammation, and ADMA levels. Metabolomics is a means to study depressive disorders and gives insights on disease etiology
Cancer cells adjust metabolic program to their specific energy needs in response to challenging microenvironment, which frequently results in cancer cell “addiction” to certain metabolic pathways. Those “addictions” could be deployed as treatment targets. Metabolic profiling by providing quantitative measure of metabolic processes offers attractive strategy for investigation of not only cancer cells “addictions” but also metabolic switches contributing to treatment resistance.
You can learn how metabolomics can be applied to research in neurodegenerative diseases in a quantitative and reproducible manner.