biocrates blog
Applications of metabolomics
Sphingosine-1-phosphate (S1P) – Metabolite of the month
In our metabolite of the month series, our scientists look at one specific metabolite each month. Topics of discussion include the biosynthesis and degradation in a broader health context, and the effect of dysregulation. In this month´s article, they took a closer look at sphingosine-1-phosphate.
Metabolite of the month – Arginine
In our metabolite of the month series, our scientists look at one specific metabolite each month. Topics of discussion include the biosynthesis and degradation in a broader health context, and the effect of dysregulation. In this month´s article, they took a closer look at Arginine.
Metabolite of the month – Deoxycholic acid
History & evolutionBiosynthesis vs. dietary uptakeDCA and the microbiomeDCA, mitochondria and neurologyDCA and cancerDCA and immunology History and evolution 1886: first isolated from ox bile (Hofmann and Hagey 2014) | 1911: first isolated from human samples...
biocrates at ASMS 2023
Delve into the firsthand experience of the biocrates team at the ASMS 2023 conference, held in Houston, Texas, with a remarkable attendance of over 5,000 participants.
Metabolomics – (not) a game changer in toxicology?
Why is metabolomics a game-changer in toxicology? We think so, but why are toxicologists split on this question?
Metabolite of the month – Alpha-aminoadipic acid
Aminoadipic acid is an alpha amino acid, meaning its amino group is attached to the carbon atom in the alpha position. It’s a nonproteinogenic amino acid found in all eukaryotes.
Cell culture metabolomics – The shortcut to drug development
Cell culture metabolomics is an excellent tool to decrease drug development costs while increasing speed and success rate. Its applicability has been proven in numerous studies.
Metabolite of the month – Aminobutyric acids
Alpha-, beta- and gamma-aminobutyric acids (AABA, BABA and GABA) are a group of structurally similar nonproteinogenic amino acids.
Metabolite of the month – Histamine
Histamine stimulates smooth muscle contraction, vasodilation, and gastric acid secretion, and plays a role in cell differentiation, proliferation and regeneration
Metabolite of the month – Glycine
Glycine plays a role in metabolic regulation, neurological function, anti-oxidative reactions and protein synthesis. It offers multiple health benefits that may help to treat diabetes, cardiovascular disease, cancer, inflammation and obesity.
3 assets needed to excel at metabolomics data interpretation
Data interpretation is often overlooked in omics training. But without knowing how to make sense of our results in the broader biological context, we’ll struggle to pull out actionable insights from our data.The biological interpretation of metabolomics is a long but...
Metabolite of the month – Ornithine
Our metabolite of the month is Ornithine, a non-essential, non-proteinogenic amino acid that plays an essential role in the urea cycle.
Phosphatidylethanolamines – Key lipids in cellular function and membrane integrity
Phosphatidylethanolamine (PE) is a sub-class of phospholipids with a variety of functions in animals, plants and microorganisms. Like other phospholipids, PEs are more than simply the building blocks of membranes
Metabolite of the month – 3-Hydroxy Glutaric Acid
3-hydroxyglutaric acid is a little known metabolite with great application for the diagnosis of a rare disease.
ICYMI – Recap from “Pan-cohort studies – the future of population health” symposium
With more than 20 hours of cutting-edge science in the rearview mirror, it’s time to reflect on our recent “Pan-cohort studies – The future of population health” event.
Metabolite of the month – Lactic acid
Lactic acid is produced by various cells in the body, including muscle cells, red blood cells and neurons
Which sample matrix should I use for my metabolomics study?
While there’s no single correct approach to figuring out your sample matrix, there certainly are things that could be done wrong. Here, we dive into some of the advantages and advantages of the sample matrices you might consider for you metabolomics study.
Metabolite of the month – NAD+ (nicotinamide adenine dinucleotide)
NAD is best known as a master regulator of redox reactions, but it is also a substrate used by many enzymes to fine tune cell biology.
MxP® Quant 500 kit for SCIEX 7500 LC-MS/MS systems
MxP® Quant 500 targeted metabolomics kit is now validated for use with SCIEX 7500 LC-MS/MS systems
Importance of pre-analytics for metabolomics studies
Pre-analytics influences metabolite concentrations. Adherence to standardized sample collection and storage protocols is crucial for reliable metabolomics data
Happy birthday biocrates
This summer, biocrates celebrates 20 years at the forefront of metabolomics. To mark the occasion and take a look back over the highlights of the last two decades, the global team got together in Innsbruck in July.
Metabolite of the month – Tryptophan
Tryptophan is a pivotal metabolite in nutrition, inflammation and the gut-brain-axis. This is an overview of what is known about this amino acid although much is left..
Metabolomics 2022 in person
In this article we share our take-aways and experience from Metabolomics 2022 in Valencia. We summarized not only exciting talks, posters and trends but also the thrill of meeting with the metabolomics community in person again.
Metabolite of the month – Cholesterol
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at cholesterol..
How to tackle health issues in animal husbandry?
Metabolomics contributes to advances in sustainable, productive livestock animal husbandry and animal welfare based on the assessment of health of farm animals.
Metabolite of the month – ADMA
Metabolite of the month is your sneak peek into the world of metabolomics. Topics of discussion include the ..
Adverse effects in immunotherapy
Only 20–30 % of patients experience a long-term benefit from immunotherapy, but the high rate of adverse events in immunotherapies is also a matter of intense research and scientific debate
Metabolite of the month – Cortisol
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at cortisol, a steroid hormone involved in stress response and beyond.
Metabolite of the month – Phosphatidylcholines
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at phosphatidylcholines, a class of lipids involved in much more than membrane composition.
Therapy resistance: could metabolomic biomarkers remove this major roadblock to successful pharmaceutical research and development programs?
Pharmaceutical therapies have created huge benefits for society in expanding healthy life span
The winners of the biocrates publishing awards
The biocrates publishing awards recognize the outstanding scientists who are using biocrates technology to make groundbreaking discoveries in the world of metabolomics and beyond.
Metabolite of the month – Indole
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at indole, a product of tryptophan..
The Metabolomist
The Metabolomist is a podcast for metabolomics researchers to connect with like-minded scientists and explore the unspoken issues in metabolomics research.
Introducing the biocrates publishing awards
The biocrates publishing awards recognize the outstanding scientists who are using biocrates technology to make groundbreaking discoveries in the world of metabolomics and beyond.
Leucine – Metabolite of the month
Metabolite of the month is your sneak peek into the world of metabolomics. This month, we look at leucine, an amino acid involved in energy metabolism, autophagy, and more.
Using MxP® Quant 500 kit with Agilent 6495B and 6495C TQ LC/MS systems
Using biocrates MxP® Quant 500 kit for broad metabolic profiling with the Agilent 6495C triple quadrupole LC/MS system
Metabolite of the month – Sphingomyelins
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at sphingomyelins, building blocks of eukaryotic cell membranes, play in cell signaling, growth, and survival.
The 8th Munich Metabolomics Symposium
Recap of the 8th Munich Metabolomics Symposium, November 12th, 2021
Isovaleric acid – Metabolite of the month
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at Isovaleric acid, a five-carbon branched ..
Why you should combine analysis of short-chain fatty acids (SCFAs) and medium-chain fatty acids (MCFAs)
Short-chain fatty acids (SCFAs) and medium-chain fatty acids (MCFAs) are well-established as important diet-based energy sources.
Metabolite of the month – Triglycerides
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at Triglycerides, complex molecules used ..
MetaboINDICATOR™
MetaboINDICATOR™ - Translate metabolomics & lipidomics into knowledge Making the most of metabolomics data Alice Limonciel, Barbara Ustaszewski, Stephen Dearth, Gordian Adam, Martin Buratti, and Therese Koal Identifying meaningful results in omic datasets remains...
Metabolite of the month – Butyric acid
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at Butyric acid, which is one of three common SCFAs in the human gut.
TMAO (Trimethylamine N-oxide) – Is it good or bad?
Trimethylamine oxide (TMAO), which has been suggested to be a “bad” metabolite
Using MxP® Quant 500 kit with Agilent 6495C TQ LC/MS systems
Using biocrates MxP® Quant 500 kit for broad metabolic profiling with the Agilent 6495C triple quadrupole LC/MS system
Creatinine – Metabolite of the month
Metabolite of the month is your sneak peek into the world of metabolomics. This month we took a closer look at creatinine, a non-protein nitrogenous waste product generated during energy breakdown in muscles.
Taurine – Regulator of cellular function
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at Taurine, the most abundant intracellular amino acid in the human body.
Metabolite of the month – Dopamine
Metabolite of the month is your sneak peek into the world of metabolomics. This month discover dopamine, a link between memory, blood pressure, and music.
Metabolite of the month – p-cresol sulfate
The metabolite of this month is p-cresol sulfate, a sulfate conjugate of the bacterial metabolite p-cresol, which is a uremic toxin.
7 tips to make your first metabolomics project successful (with story)
To obtain optimal results from your metabolomics project you might want to answer these seven questions to increase your success.
Spermidine : Unlocking the secrets of cellular aging and longevity
The metabolite of this month is spermidine, a biogenic amine with applications in cancer, neurology and hair research.
Pan-Cohort Metabolomics – The future of population health
Epidemiological research contributes greatly to our understanding of what constitutes healthy aging. Cohort studies hold the key to identifying risk factors for common diseases. Metabolomics is a valuable tool to make cohort studies successful.
Cholic acid – a signaling molecule
The metabolite of this month is cholic acid, of the the bile acid class. Notorious for their role in digestion, they are also powerful regulators of metabolism.
Arachidonic acid – Essential fatty acid with key roles in inflammation and cell signaling
The metabolite of this month is arachidonic acid, a polyunsaturated fatty acid at the crossroads between inflammation, athlete training and the latest COVID-19 research.
COVID-19 – Metabolomics prediction of long-term outcome
Those who recover from COVID-19, especially after severe cases, have experienced a great deal of pain and discomfort. However, because of potential multi-organ injuries that more closely resemble the situation after sepsis rather than recovery from an Influenza virus infection, COVID-19 survivors often experience long-term consequences of the infection.
COVID-19 Utility of animal models
The global impact of the COVID-19 pandemic has prompted collaborative research efforts across the world. Thus far, the bulk of these efforts have been geared towards vaccine development and discovery of therapeutic strategies that mitigate disease severity.
Metabolomics and response to SARS-CoV-2 vaccination
While vaccine development has been faster than for any previous emerging infectious disease, the next big challenge will be the logistics of producing and distributing hundreds of millions of doses.
Metabolic interaction of COVID-19 and metabolic diseases
It is well established that within the context of infectious diseases, both host and pathogen impact each other’s metabolism. Viral diseases, such as COVID-19, perfectly exemplify this, as the virus hijacks host cells in order to survive and replicate.
Kynurenine – Metabolite of the month
Kynurenine is a tryptophan-derived metabolite at the crossroads between neurology, immunology and cancer
Metabolite of the month – Carnitine
Metabolite of the month is your sneak peek into the world of metabolomics. This month we look at carnitine #loveyourmetabolites
Is Alzheimer’s a metabolic disease?
Alzheimer’s disease (AD) has many facets. Metabolomics supports Alzheimer’s early diagnosis and research on the treatment of AD.
Therapy response monitoring in infectious diseases
Monitoring COVID-19 patient’s pathophysiology using metabolomics can lead to early detection of therapy response, opening an avenue to precision medicine.
Metabolomics and COVID-19
Monitoring COVID-19 patient’s pathophysiology might lead to early detection of therapy response, opening an avenue to precision medicine. Metabolomics is a tool to support these efforts.
Best practices for feces metabolomics
biocrates enables reproducible quantitative metabolomics in fecal samples. Understand the challenges associated with this matrix.
Webinar report – Metabolomics, Nutrition, Microbiome
“Metabolomics – between Nutrition, Microbiome, and Disease” demonstrates that metabolomics is a powerful tool to study host-microbiota-diet interactions
What urine can tell about the metabolome
Biocrates enables reproducible quantitative metabolomics in urine samples, a biofluid of choice for biomarker discovery in medicine and biology.