Read in this article about how exposomics and metabolomics together provide a powerful, complementary framework for advancing 5P medicine by linking environmental exposures with measurable metabolic phenotypes.
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Immunotherapy response | Metabolomics accelerating 5P medicine
Metabolomics as an accelerator of 5P medicine |
Part 1: Polyamine acetylation as a driver of immunotherapy response
2025 at biocrates – A year shaped by 5P medicine
2025 was a year shaped by 5P medicine for biocrates. From the evolution of our scientific content to new product highlights and our integration into the Biognosys Group, this year demonstrated how metabolomics brings the five pillars of modern medicine – preventive, predictive, precision, population-based, and participatory – to life.
Participatory medicine – Transform medicine with metabolomics – part 5 of 5
In this five-part blog series, Alice Limonciel explores the role of metabolomics in 5P medicine. In this final article of our 5P medicine series, we explore how metabolomics empowers participatory medicine by enabling patients to collect meaningful health data from home.
Metabolomics 2025 | A conference worth 1000 words
The metabolomics community came together at the Metabolomics Society’s annual “MetSoc” conference in Prague to explore the latest developments and future directions in the field.
Population based medicine – Transform medicine with metabolomics – part 4 of 5
In this five-part blog series, Alice Limonciel explores the role of metabolomics in 5P medicine. In this 3rd article she explores how metabolomics is driving real-world applications of precision medicine, especially in predictive diagnostics, treatment optimization, and personalized nutrition. Learn why sex-based data stratification is essential, how metabolic profiles reveal hidden disease subtypes, and why the future of medicine is personal.
Spermidine – Unlocking the secrets of cellular aging and longevity
The metabolite of this month is spermidine, a biogenic amine with applications in cancer, neurology and hair research.
Precision medicine – Transform medicine with metabolomics – part 3 of 5
In this five-part blog series, Alice Limonciel explores the role of metabolomics in 5P medicine. In this 3rd article she explores how metabolomics is driving real-world applications of precision medicine, especially in predictive diagnostics, treatment optimization, and personalized nutrition. Learn why sex-based data stratification is essential, how metabolic profiles reveal hidden disease subtypes, and why the future of medicine is personal.
Propionic acid – A short-chain fatty acid with big impact
A short-chain fatty acid produced by gut, it plays a role in energy metabolism, immune regulation, and neurological health
Predictive medicine – Transform medicine with metabolomics – part 2 of 5
In this five-part blog series, Alice Limonciel explores the role of metabolomics in 5P medicine. This second installment highlights how screening samples with broad metabolomics panels and leveraging data with knowledge-driven tools leads to the translation of metabolomics insights into innovative strategies for predictive medicine.
Preventive medicine – Transform medicine with metabolomics – part 1 of 5
This is the first in a series of five blogs where Alice Limonciel discusses how metabolomics is set to transform medicine as we know it. The applications of omics in biomedical research are vast, and to help organize the different ways metabolomics can be used, I’ll discuss this in the context of 5P medicine.
Introduction to metabolomics in action
This lunch and learn event, sponsored by biocrates life sciences and hosted by Dr. Candace Guerrero, Assistant Director of the Center for Metabolomics and Proteomics at UMN, will feature presentations on cutting-edge research in metabolomics.
Investigating the stool and plasma metabolome of people with HIV
This lunch and learn event, sponsored by biocrates life sciences and hosted by Dr. Candace Guerrero, Assistant Director of the Center for Metabolomics and Proteomics at UMN, will feature presentations on cutting-edge research in metabolomics.
Metabolomics of sepsis and critical illness
This lunch and learn event, sponsored by biocrates life sciences and hosted by Dr. Candace Guerrero, Assistant Director of the Center for Metabolomics and Proteomics at UMN, will feature presentations on cutting-edge research in metabolomics.
Developing a baseline metabolomic signature associated with COVID-19 severity: Insights from prospective trials encompassing 13 U.S. centers
This lunch and learn event, sponsored by biocrates life sciences and hosted by Dr. Candace Guerrero, Assistant Director of the Center for Metabolomics and Proteomics at UMN, will feature presentations on cutting-edge research in metabolomics.
Metabolomics in pharma – Bridging R&D translation barriers
In this lunch & learn event Marissa Jones shared insights on using metabolomics to uncover the “why” behind your research. Examine real-world case studies. and see biocrates technology in action. Learn how metabolomics is making an impact in the pharmaceutical industry.
The new dogma of microbial bile acid metabolism
In my talk, I will present the new dogma of microbial bile acid metabolism.
Characterizing the metabolome in pediatric severe traumatic brain injury
In this talk, I will discuss the characterization of the metabolome in pediatric severe traumatic brain injury.
Inosine – Metabolite of the month
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at inosine.
mGWAS – Integrating metabolomics in genome-wide association studies for more precise results
Combining genome-wide association studies (GWAS) with metabolomics and Mendelian randomization is transforming precision medicine by uncovering causal links between genetic variants and clinical outcomes, rather than just correlations.
3 words to capture Metabolomics 2024
ASMS 2024, a main event for the mass spectrometry community, showcased the latest advancements in mass spectrometry and fostered important collaborations in the field of metabolomics.
Mass spectrometry in metabolomics – From methodologies to applications
Metabolomics highlights the significant role of microbial communities in human health, driving a paradigm shift towards towards personalized, proactive healthcare.
Does metabolomics have a place in microbiome research?
Metabolomics highlights the significant role of microbial communities in human health, driving a paradigm shift towards towards personalized, proactive healthcare.
p-cresol sulfate – A key uremic toxin with implications for gut health and chronic disease
The metabolite of this month is p-cresol sulfate, a sulfate conjugate of the bacterial metabolite p-cresol, which is a uremic toxin.
Alpha-pinene – The terpene with powerful anti-inflammatory and respiratory benefits
As one of the metabolites responsible for the smell of conifers, alpha-pinene is a fitting choice for our festive Metabolite of the month.
The fluid of everything – Urine and precision nutrition
How urine metabolomics advances precision nutrition by enabling personalized, effective, and proactive dietary recommendations.
Cinnamaldehyde – The bioactive compound with potent anti-inflammatory and antioxidant properties
In our metabolite of the month series, our scientists look at one specific metabolite each month. Topics of discussion include the biosynthesis and degradation in a broader health context, and the effect of dysregulation. In this month´s article, they took a closer look at Cinnamaldehyde.
Cell culture metabolomics – The shortcut to drug development
Cell culture metabolomics is an excellent tool to decrease drug development costs while increasing speed and success rate. Its applicability has been proven in numerous studies.
A metabolomics perspective on major depressive disorder
Depression has an impact on nitric oxide synthesis, urea cycle, inflammation, and ADMA levels. Metabolomics is a means to study depressive disorders and gives insights on disease etiology
Targeted metabolomics in neurodegenerative diseases
You can learn how metabolomics can be applied to research in neurodegenerative diseases in a quantitative and reproducible manner.
3 assets needed to excel at metabolomics data interpretation
Data interpretation is often overlooked in omics training. But without knowing how to make sense of our results in the...
Phosphatidylethanolamines – Key lipids in cellular function and membrane integrity
Phosphatidylethanolamine (PE) is a sub-class of phospholipids with a variety of functions in animals, plants and microorganisms. Like other phospholipids, PEs are more than simply the building blocks of membranes
Metabolite – 3-Hydroxy Glutaric Acid (A biomarker for a rare disease)
3-hydroxyglutaric acid is a little known metabolite with great application for the diagnosis of a rare disease.
NAD+ (nicotinamide adenine dinucleotide) – Metabolite of the month
NAD is best known as a master regulator of redox reactions, but it is also a substrate used by many enzymes to fine tune cell biology.
Importance of pre-analytics for metabolomics studies
Pre-analytics influences metabolite concentrations. Adherence to standardized sample collection and storage protocols is crucial for reliable metabolomics data
Happy birthday biocrates
This summer, biocrates celebrates 20 years at the forefront of metabolomics. To mark the occasion and take a look back over the highlights of the last two decades, the global team got together in Innsbruck in July.
Metabolomics 2022 in person
In this article we share our take-aways and experience from Metabolomics 2022 in Valencia. We summarized not only exciting talks, posters and trends but also the thrill of meeting with the metabolomics community in person again.
Asymmetric dimethyl arginine (ADMA) – Metabolite of the month
Metabolite of the month is your sneak peek into the world of metabolomics. Topics of discussion include the ..
The Metabolomist
The Metabolomist is a podcast for metabolomics researchers to connect with like-minded scientists and explore the unspoken issues in metabolomics research.
Using MxP® Quant 500 kit with Agilent 6495B and 6495C TQ LC/MS systems
Using biocrates MxP® Quant 500 kit for broad metabolic profiling with the Agilent 6495C triple quadrupole LC/MS system
Sphingomyelins – Metabolite of the month
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at sphingomyelins, building blocks of eukaryotic cell membranes, play in cell signaling, growth, and survival.
Metabolomics unravels aspects of Alzheimer’s disease
Metabolites and genetic markers help to enlighten aspects of Alzheimer’s disease
Are effects of antibiotics reflected in the metabolome?
Antibiotics influence the gut microbiome and the plasma or fecal metabolome depending on the class of antibiotics and the gut bacterial composition.
Why you should combine analysis of short-chain fatty acids (SCFAs) and medium-chain fatty acids (MCFAs)
Short-chain fatty acids (SCFAs) and medium-chain fatty acids (MCFAs) are well-established as important diet-based energy sources.
Triglycerides – Metabolite of the month
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at Triglycerides, complex molecules used ..
Metabotypes applied to dairy production
Metabotypes help categorize dairy cows with different lactation yields
MetaboINDICATOR™
MetaboINDICATOR™ - Translate metabolomics & lipidomics into knowledge Making the most of metabolomics data Alice...
Using MxP® Quant 500 kit with Agilent 6495C TQ LC/MS systems
Using biocrates MxP® Quant 500 kit for broad metabolic profiling with the Agilent 6495C triple quadrupole LC/MS system
Lipid biomarkers improve diagnosis of bacterial meningitis
Free phosphatidylcholines in cerebrospinal fluid are highly promising biomarkers for an improved differential diagnosis of bacterial meningitis.
New analytical method for the quantification of acylcarnitines
Acylcarnitine profiles of melanoma xenografts in mice could be a step towards a new treatment.
Metabolite of the month – Dopamine
Metabolite of the month is your sneak peek into the world of metabolomics. This month discover dopamine, a link between memory, blood pressure, and music.
Could metabolites enhance pharmacological cancer treatments?
Metabolites in action: metabolomics reveals link between mitochondrial respiration and proteasomal degradation mechanisms, with important implications for cancer drugs.
Modulating gut microbiota with prebiotics could control type 2 diabetes
Modulation of gut microbiota with prebiotic Fructooligosaccharides (FOS) led to discovery of two novel enterosynes (12-HETE and enkephalin), with potential to control type 2 diabetes
Blood-based score objectively captures dietary patterns
A blood-based predictive metabolomics score provides a tool linking dietary patterns to risk of diabetes that can be used to objectively assess dietary intake.
Microbiome instability and host metabolic dysfunctions
Plasma metabolome and microbiota profiles from the SHIP cohort link microbiome instability to liver steatosis, diabetes mellitus, and pancreatic dysfunction
Circulating metabolites shed light on mechanism of action
The changes in circulating metabolites induced by a multi-AGC kinase inhibitor in mice and patients may contribute to better understand its mechanism of action.
Cholic acid – a signaling molecule
The metabolite of this month is cholic acid, of the the bile acid class. Notorious for their role in digestion, they are also powerful regulators of metabolism.
Arachidonic acid – Essential fatty acid with key roles in inflammation and cell signaling
The metabolite of this month is arachidonic acid, a polyunsaturated fatty acid at the crossroads between inflammation, athlete training and the latest COVID-19 research.
Prediction of cancer survival rate with metabolomics
Metabolomics can be combined with clinical data for the prediction of patient survival after anti-tumor treatment.
COVID-19 Utility of animal models
The global impact of the COVID-19 pandemic has prompted collaborative research efforts across the world. Thus far, the bulk of these efforts have been geared towards vaccine development and discovery of therapeutic strategies that mitigate disease severity.
Kynurenine metabolites mediate neuromuscular dysfunction
Accumulation of neurotoxic kynurenine metabolites with aging represents the mechanism of neuromuscular defects linking chronic inflammation to physical frailty.
Kynurenine – Metabolite of the month
Kynurenine is a tryptophan-derived metabolite at the crossroads between neurology, immunology and cancer
Machine learning for ALS progression biomarker discovery
How to combine targeted metabolomics and machine learning algorithms to identify biomarkers associated with ALS disease progression.
Bile acids and newborn’s gut microbiota maturation
The maturation of the newborn´s microbiome is critically dependent on bile acids from liver and can be manipulated by administration of bile acids in mice.
Circulating metabolites predict coronary heart disease risk
Serum metabolites were associated with risk of coronary heart disease in a population-based cohort, with a comparable strength to classic risk factors.
Carnitine – Metabolite of the month
Metabolite of the month is your sneak peek into the world of metabolomics. This month we look at carnitine #loveyourmetabolites
Elevated serum bile acid levels contribute to NASH-HCC
Higher serum bile acid levels and an altered gut microbiome contribute to fibrogenesis, liver injury, and tumorigenesis in cirrhotic and noncirrhotic NASH-HCC.
Mitochondria’s role in clinical depression
What does brain activity look like after anti-depressant treatment and what is the basis for prescribing serotonin re-uptake inhibitors in the first place?
Gut microbiota and statins
Metabolomics and 16S rRNA profiling uncover the crosstalk between gut microbiota and statins efficacy that can hide behind inter-individual variability.
Lipidomics in cardiac patients after the Fontan procedure
Lipidomics reveals long-term effects of palliative surgeries in Fontan patients after cardiac function is restored.
Best practices for feces metabolomics
biocrates enables reproducible quantitative metabolomics in fecal samples. Understand the challenges associated with this matrix.
The metabolic cost of a marathon: fitness matters
Targeted metabolomics reveals differences in metabolic profiles between top athletes and amateur runners days after running a marathon.
Amino acids aid in diagnosis of tuberculosis infection
Amino acids were identified as serum biomarkers for the diagnosis of patients with active tuberculosis infection in a targeted metabolomics study.
Metabolomics in Multiple Sclerosis
Finding a test for different types of multiple sclerosis has been proven to be difficult. Metabolomics as a solution is explored in the study portrayed here.
Webinar report – Metabolomics, Nutrition, Microbiome
“Metabolomics – between Nutrition, Microbiome, and Disease” demonstrates that metabolomics is a powerful tool to study host-microbiota-diet interactions
What urine can tell about the metabolome
Biocrates enables reproducible quantitative metabolomics in urine samples, a biofluid of choice for biomarker discovery in medicine and biology.
Obesity and the microbiome
Metagenomics, metaproteomics and metabolomics create an exciting mix of approaches to understand systematic changes in an organism after external perturbations.
Does metabolic syndrome manifest itself differently?
An international team of scientists applied targeted metabolomics to deepen the mechanistic understanding of metabolic syndrome and its regional specificities.
Which metabolites tell your diet?
Uncovering the mechanism linking the Mediterranean diet with reduced risk for cardiometabolic diseases using targeted metabolomics.
Could probiotics replace antibiotics?
How can the use of antibiotics in animal farming be reduced? Probiotics might be a solution.
Make sure your drug fits to your cancer
The response of cancer cells to checkpoint inhibition therapy can be predicted using metabolomics.
Arginine metabolism: Targeted metabolomics and biochemical pathways
Metabolic syndrome is associated with changes in amino acid metabolites. The korean genome and epidemiology study finds involvement of arginase activity
Feature: MetaboINDICATOR and biogenic amines
Targeted metabolomics support the study of animal health. The diet of cows (high vs low energy) has influence on the metabolite levels of the offspring.
Gender differences in brain – revealed by metabolomics
Female and male mice may think differently. Targeted metabolomics reveals differences in brain chemistry between the two which might account for behavioral differences.
A metabolic profile of all-cause mortality risk
To predicting life expectancy standardized and reproducible scientific methods are needed. Metabolomics is one way to approach this question.
Betaine for a healthy life and brain?
Betaine supplementation has a profound effect on phospholipid metabolism. Its effect on brain and liver health can be studied using targeted metabolomics.
Serine – nonessential for you, but essential for cancer
One of the widely accepted hallmarks of cancer is metabolic deregulation. By integrating transcriptome, proteome, and metabolome analysis insights on cancer can be gained.
Microbiome and cognition in Alzheimer´s disease
Due to the fact that in Alzheimers bile acids as well as the microbiome play a key role, standardized metabolomics is particularly well adapted to study Alzheimers.
Metabolomics can indicate favorable response to microbiota transfer
The study of the microbiome is a vital part of personalized medicine. Targeted metabolomics supports patient stratification in Clostridiodes patients.
Metabolomics of acute heart failure
Acute and chronic heart failure can be studied using metabolomics. The metabolic phenotype (especially lipids/ amino acids) rapidly changes upon these condition
Nutrition might still improve your health
The health benefits of Omega 3 fatty acids are well documented. Metabolomics studies can help to elucidate the beneficial effects of nutrition on body and mind.
Upcoming events
Metabolomics Society 2026
This year's annual international meeting "Metabolomics Society Conference 2026" will bring together researchers, industry experts, and thought leaders to share the latest advances in metabolomics through keynote talks, scientific sessions, and networking opportunities.
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