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Nicotinic acid has evolved from a pellagra-curing vitamin to a context‑dependent metabolic modulator, linking vitamin B₃ biology with NAD⁺ metabolism, lipid regulation, immunity, and host–microbiome interactions. Its history and mechanisms exemplify how nutritional discoveries have shaped modern precision approaches to cardiometabolic and inflammatory disease.
Read in this article about how exposomics and metabolomics together provide a powerful, complementary framework for advancing 5P medicine by linking environmental exposures with measurable metabolic phenotypes.
Eicosapentaenoic acid (EPA) is an omega‑3 polyunsaturated fatty acid that acts as a precursor to specialized pro‑resolving mediators, including resolvins, which actively dampen inflammatory responses.
Metabolomics as an accelerator of 5P medicine |
Part 1: Polyamine acetylation as a driver of immunotherapy response
Dimethylglycine is a molecular entry point into individualized, systems-oriented healthcare. Altered DMG levels have been linked to cardiometabolic risk and conditions such as myocardial infarction, diabetes, and metabolic dysfunction-associated liver disease.