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cAMP – a currency of cell signaling
Cyclic adenosine monophosphate (cAMP) is a universal second messenger which translates extracellular cues into cellular responses regulating metabolism, gene expression, neurobiology, and immunity. Dysregulated cAMP signaling contributes to cancer, inflammation, and neurological disorders, making it a key target in precision medicine.
Methylmalonic acid – key marker of vitamin B12 status and metabolism
Methylmalonic acid (MMA) is a key biomarker of vitamin B12 deficiency and plays a central role in energy metabolism.
UDCA – reducing inflammation and supporting bile flow
The metabolite of this month is UDCA, a secondary bile acid metabolite which plays a significant role in hepatology, neurology, and gastrointestinal research.
Precision nutrition – Unlocking health through metabolomics
Discover how metabolomics drives precision nutrition, offering personalized insights into the connection between diet, well-being, and healthier lifestyles.
How to tackle health issues in animal husbandry?
Metabolomics contributes to advances in sustainable, productive livestock animal husbandry and animal welfare based on the assessment of health of farm animals.
Short-term air pollution alters amino acid metabolism
Well-defined exposure to air pollution reveals distinct perturbations of amino acid metabolism
Prediction of bladder cancer progression
A multi-OMICS approach identified metabolic signatures related to fatty acid oxidation in bladder cancer progression.
Alterations in metabolism might cause chronic kidney disease
Chronic kidney disease and impaired renal function shown to be associated with a variety of metabolites, suggesting the involvement of several metabolic pathways in the disease pathophysiology.
Pharmacometabolomics provides biomarkers for precision medicine
A combination of various technologies in pharmacometabolomics enables biomarker discovery for prediction of drug responses of individual patients.
Distinct metabolic alterations in cancer- and chemotherapy-induced cachexia
Cancer in comparison to chemotherapy cause distinct metabolic perturbations, which both lead to the development and progression of cachexia characterized by extreme weight loss and muscle wasting.
Effect of proton pump inhibitor use on development of cardiovascular diseases
Population-based cohort study reveals link between proton pump inhibitor intake and increasing risk for cardiovascular events.
Irritable bowel syndrome linked to distinct metabolic profile
A metabolic pattern of patients with irritable bowel syndrome (IBS) was identified, providing the key to non-invasive IBS diagnostics.
Dyslipidemia contributes to cardiac autonomic neuropathy in type 2 diabetes
Cardiac autonomic neuropathy is linked to perturbations of the lipid metabolism specifically in Type 2 Diabetes.
Elevated liver fat content disrupts the liver-α cell axis
Elevated liver fat is related to hyperglucagonaemia, which reflects the disruption of the liver-α cell axis.
How bile salt hydrolases affect the gut microbiome
Bile acid composition and a complex network of bile salt hydrolases in the gut shape microbial colonization.
Prenatal PFAS exposure leads to liver injuries in children
HELIX metabolomics study links prenatal PFAS (perfluoralkyl substances) exposure to metabolic origin of liver injuries in children.
Mechanism of gallstone formation
Chromatin mesh of specific immune cells aggregates bile crystals to gallstones and might constitute a promising pharmacological target against gallstone formation.
Giardia lamblia alters bile acid secretion in mice
A neonatal mouse model demonstrated that G. lamblia infection altered the composition of the gut microbiome and enhanced bile acid secretion and deconjugation.
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