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Nicotinic acid has evolved from a pellagra-curing vitamin to a context‑dependent metabolic modulator, linking vitamin B₃ biology with NAD⁺ metabolism, lipid regulation, immunity, and host–microbiome interactions. Its history and mechanisms exemplify how nutritional discoveries have shaped modern precision approaches to cardiometabolic and inflammatory disease.
Dimethylglycine is a molecular entry point into individualized, systems-oriented healthcare. Altered DMG levels have been linked to cardiometabolic risk and conditions such as myocardial infarction, diabetes, and metabolic dysfunction-associated liver disease.
Fructose is a simple sugar found in fruits and honey, but also added to many processed foods. Unlike glucose, it is mainly metabolized in the liver, and excessive intake can contribute to metabolic and inflammatory health issues.
biocrates’ standardized metabolomics empowers global research. Here is a selection of how our community of users has translated molecular fingerprints into insights for 5P medicine in 2025.
p-cresol glucuronide (pCG) is a liver-derived conjugate of the gut microbial metabolite p-cresol, excreted via the kidneys, and it reflects gut-microbiome activity in blood and urine.
Explore how disruptions in peroxisomal lipid metabolism drive disease phenotypes and how lipidomics can reveal early biomarkers of rare disorders.
Cyclic adenosine monophosphate (cAMP) is a universal second messenger which translates extracellular cues into cellular responses regulating metabolism, gene expression, neurobiology, and immunity. Dysregulated cAMP signaling contributes to cancer, inflammation, and neurological disorders, making it a key target in precision medicine.
Methylmalonic acid (MMA) is a key biomarker of vitamin B12 deficiency and plays a central role in energy metabolism.
The metabolite of this month is UDCA, a secondary bile acid metabolite which plays a significant role in hepatology, neurology, and gastrointestinal research.
Discover how metabolomics drives precision nutrition, offering personalized insights into the connection between diet, well-being, and healthier lifestyles.
Metabolomics contributes to advances in sustainable, productive livestock animal husbandry and animal welfare based on the assessment of health of farm animals.
Well-defined exposure to air pollution reveals distinct perturbations of amino acid metabolism
A multi-OMICS approach identified metabolic signatures related to fatty acid oxidation in bladder cancer progression.
Chronic kidney disease and impaired renal function shown to be associated with a variety of metabolites, suggesting the involvement of several metabolic pathways in the disease pathophysiology.
A combination of various technologies in pharmacometabolomics enables biomarker discovery for prediction of drug responses of individual patients.
Cancer in comparison to chemotherapy cause distinct metabolic perturbations, which both lead to the development and progression of cachexia characterized by extreme weight loss and muscle wasting.
Population-based cohort study reveals link between proton pump inhibitor intake and increasing risk for cardiovascular events.
A metabolic pattern of patients with irritable bowel syndrome (IBS) was identified, providing the key to non-invasive IBS diagnostics.
Cardiac autonomic neuropathy is linked to perturbations of the lipid metabolism specifically in Type 2 Diabetes.
Elevated liver fat is related to hyperglucagonaemia, which reflects the disruption of the liver-α cell axis.
Bile acid composition and a complex network of bile salt hydrolases in the gut shape microbial colonization.
HELIX metabolomics study links prenatal PFAS (perfluoralkyl substances) exposure to metabolic origin of liver injuries in children.
Chromatin mesh of specific immune cells aggregates bile crystals to gallstones and might constitute a promising pharmacological target against gallstone formation.
A neonatal mouse model demonstrated that G. lamblia infection altered the composition of the gut microbiome and enhanced bile acid secretion and deconjugation.
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