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biocrates Sysadmin
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment. Less than half of all patients respond to the primary treatment for PDAC, chemotherapy, and genetic alterations alone cannot explain this. Using shotgun metagenomic sequencing and metabolomic screening, we show that the microbiota-derived tryptophan metabolite indole-3-acetic acid (3-IAA) is enriched in patients who respond to treatment.

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Advancing cancer treatment by targeting dysregulated metabolism – A roadmap

Advancing cancer treatment by targeting dysregulated metabolism – A roadmap

Cancer cells adjust metabolic program to their specific energy needs in response to challenging microenvironment, which frequently results in cancer cell “addiction” to certain metabolic pathways. Those “addictions” could be deployed as treatment targets. Metabolic profiling by providing quantitative measure of metabolic processes offers attractive strategy for investigation of not only cancer cells “addictions” but also metabolic switches contributing to treatment resistance.

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Upcoming events

Host-microbiome dynamics

Date May 10 - 12, 2026Time All Day EventVenue Bruges Meeting & Convention Centre – Bruges, Belgium

This year's Cell Press Symposia Host–Microbiome Dynamics (2026) convenes leading experts to examine how microbial ecology, host biology, and immune interactions influence human health and drive new therapeutic approaches. The conference takes place at Bruges Meeting &...

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18th Scientific Days of RFMF

Date May 19 - 22, 2026Time All Day EventVenue Lille Grand Palais – France

The 18th RFMF Scientific Days, taking place in Lille from May 19–22, 2026, will gather the francophone metabolomics and fluxomics community for four days of scientific exchange, featuring invited talks, thematic sessions, poster presentations, and opportunities for yo...

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