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Cinnamaldehyde – The bioactive compound with potent anti-inflammatory and antioxidant properties

Cinnamaldehyde – The bioactive compound with potent anti-inflammatory and antioxidant properties

In our metabolite of the month series, our scientists look at one specific metabolite each month. Topics of discussion include the biosynthesis and degradation in a broader health context, and the effect of dysregulation. In this month´s article, they took a closer look at Cinnamaldehyde.

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Sphingosine-1-phosphate (S1P) – A master regulator in cellular signaling and disease pathways

Sphingosine-1-phosphate (S1P) – A master regulator in cellular signaling and disease pathways

In our metabolite of the month series, our scientists look at one specific metabolite each month. Topics of discussion include the biosynthesis and degradation in a broader health context, and the effect of dysregulation. In this month´s article, they took a closer look at sphingosine-1-phosphate.

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Arginine – Essential amino acid driving nitric oxide production and cardiovascular health

Arginine – Essential amino acid driving nitric oxide production and cardiovascular health

In our metabolite of the month series, our scientists look at one specific metabolite each month. Topics of discussion include the biosynthesis and degradation in a broader health context, and the effect of dysregulation. In this month´s article, they took a closer look at Arginine.

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Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment. Less than half of all patients respond to the primary treatment for PDAC, chemotherapy, and genetic alterations alone cannot explain this. Using shotgun metagenomic sequencing and metabolomic screening, we show that the microbiota-derived tryptophan metabolite indole-3-acetic acid (3-IAA) is enriched in patients who respond to treatment.

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Advancing cancer treatment by targeting dysregulated metabolism – A roadmap

Advancing cancer treatment by targeting dysregulated metabolism – A roadmap

Cancer cells adjust metabolic program to their specific energy needs in response to challenging microenvironment, which frequently results in cancer cell “addiction” to certain metabolic pathways. Those “addictions” could be deployed as treatment targets. Metabolic profiling by providing quantitative measure of metabolic processes offers attractive strategy for investigation of not only cancer cells “addictions” but also metabolic switches contributing to treatment resistance.

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