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biocrates Sysadmin
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment. Less than half of all patients respond to the primary treatment for PDAC, chemotherapy, and genetic alterations alone cannot explain this. Using shotgun metagenomic sequencing and metabolomic screening, we show that the microbiota-derived tryptophan metabolite indole-3-acetic acid (3-IAA) is enriched in patients who respond to treatment.

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Advancing cancer treatment by targeting dysregulated metabolism – A roadmap

Advancing cancer treatment by targeting dysregulated metabolism – A roadmap

Cancer cells adjust metabolic program to their specific energy needs in response to challenging microenvironment, which frequently results in cancer cell “addiction” to certain metabolic pathways. Those “addictions” could be deployed as treatment targets. Metabolic profiling by providing quantitative measure of metabolic processes offers attractive strategy for investigation of not only cancer cells “addictions” but also metabolic switches contributing to treatment resistance.

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Upcoming events

Arizona Metabolomics Symposium 2026

Date February 20, 2026Time All Day EventVenue Arizona State University

Join us at the Arizona Metabolomics Symposium 2026, an event exploring the latest developments in metabolomics research, its applications in health and metabolism, and fostering collaboration among scientists and the public. Attendees will hear from leading experts and ...

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Annual conference DGMS 2026

Date Mar 10 - 13, 2026Time All Day EventVenue Universität Leipzig

The 57th Annual Conference of the DGMS, dedicated to the diversity and innovative potential of mass spectrometry across instrumentation, analytical strategies, and interdisciplinary applications, will bring together researchers, postdocs and experts for scientific talks...

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