Tryptophan is a pivotal metabolite in nutrition, inflammation and the gut-brain-axis. This is an overview of what is known about this amino acid although much is left..
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Metabolite of the month – Cholesterol
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at cholesterol..
Adverse effects in immunotherapy
Only 20–30 % of patients experience a long-term benefit from immunotherapy, but the high rate of adverse events in immunotherapies is also a matter of intense research and scientific debate
The 8th Munich Metabolomics Symposium
Recap of the 8th Munich Metabolomics Symposium, November 12th, 2021
Prediction of bladder cancer progression
A multi-OMICS approach identified metabolic signatures related to fatty acid oxidation in bladder cancer progression.
Distinct metabolic alterations in cancer- and chemotherapy-induced cachexia
Cancer in comparison to chemotherapy cause distinct metabolic perturbations, which both lead to the development and progression of cachexia characterized by extreme weight loss and muscle wasting.
New analytical method for the quantification of acylcarnitines
Acylcarnitine profiles of melanoma xenografts in mice could be a step towards a new treatment.
Circulating metabolites shed light on mechanism of action
The changes in circulating metabolites induced by a multi-AGC kinase inhibitor in mice and patients may contribute to better understand its mechanism of action.
Prediction of cancer survival rate with metabolomics
Metabolomics can be combined with clinical data for the prediction of patient survival after anti-tumor treatment.
Elevated serum bile acid levels contribute to NASH-HCC
Higher serum bile acid levels and an altered gut microbiome contribute to fibrogenesis, liver injury, and tumorigenesis in cirrhotic and noncirrhotic NASH-HCC.