Population-based cohort study reveals link between proton pump inhibitor intake and increasing risk for cardiovascular events.
Effect of proton pump inhibitor use on development of cardiovascular diseases
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Pharmacology
Metabolism of fatty liver disease and the impact of therapy
New study demonstrates the power of metabolomics in boosting our understanding of fatty liver disease – and possible treatments. Obeticholic acid reverses metabolic changes in NASH.
Could metabolites enhance pharmacological cancer treatments?
Metabolites in action: metabolomics reveals link between mitochondrial respiration and proteasomal degradation mechanisms, with important implications for cancer drugs.
Circulating metabolites shed light on mechanism of action
The changes in circulating metabolites induced by a multi-AGC kinase inhibitor in mice and patients may contribute to better understand its mechanism of action.
Make sure your drug fits to your cancer
The response of cancer cells to checkpoint inhibition therapy can be predicted using metabolomics.