biocrates blog
Applications of metabolomics
Advancing cancer treatment by targeting dysregulated metabolism – A roadmap
Cancer cells adjust metabolic program to their specific energy needs in response to challenging microenvironment, which frequently results in cancer cell “addiction” to certain metabolic pathways. Those “addictions” could be deployed as treatment targets. Metabolic profiling by providing quantitative measure of metabolic processes offers attractive strategy for investigation of not only cancer cells “addictions” but also metabolic switches contributing to treatment resistance.
Targeted metabolomics in neurodegenerative diseases
You can learn how metabolomics can be applied to research in neurodegenerative diseases in a quantitative and reproducible manner.
3 assets needed to excel at metabolomics data interpretation
Ornithine – Metabolite of the month
Our metabolite of the month is Ornithine, a non-essential, non-proteinogenic amino acid that plays an essential role in the urea cycle.
Phosphatidylethanolamines – Key lipids in cellular function and membrane integrity
Phosphatidylethanolamine (PE) is a sub-class of phospholipids with a variety of functions in animals, plants and microorganisms. Like other phospholipids, PEs are more than simply the building blocks of membranes
Metabolite – 3-Hydroxy Glutaric Acid (A biomarker for a rare disease)
3-hydroxyglutaric acid is a little known metabolite with great application for the diagnosis of a rare disease.
ICYMI – Recap from “Pan-cohort studies – the future of population health” symposium
With more than 20 hours of cutting-edge science in the rearview mirror, it’s time to reflect on our recent “Pan-cohort studies – The future of population health” event.
Lactic acid – Metabolite of the month
Lactic acid is produced by various cells in the body, including muscle cells, red blood cells and neurons
Which sample matrix should I use for my metabolomics study?
While there’s no single correct approach to figuring out your sample matrix, there certainly are things that could be done wrong. Here, we dive into some of the advantages and advantages of the sample matrices you might consider for you metabolomics study.
NAD+ (nicotinamide adenine dinucleotide) – Metabolite of the month
NAD is best known as a master regulator of redox reactions, but it is also a substrate used by many enzymes to fine tune cell biology.