biocrates blog
Applications of metabolomics
Host-microbial interactions as pathophysiological nexus in inflammatory bowel disease
Immunometabolism is an important component to the pathophysiology of inflammatory bowel diseases and thus may serve the purpose of contributing to better and more personalized therapy decisions. While several metabolic pathways contribute, the talk puts special emphasis on the metabolism of the essential amino acid tryptophan.
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment. Less than half of all patients respond to the primary treatment for PDAC, chemotherapy, and genetic alterations alone cannot explain this. Using shotgun metagenomic sequencing and metabolomic screening, we show that the microbiota-derived tryptophan metabolite indole-3-acetic acid (3-IAA) is enriched in patients who respond to treatment.
Metabolomics as a tool to stratify patients and guide therapeutic decisions
Metabolomics can be used to develop tools to help guide therapy decisions in multiple ways, e.g. predict whether a drug will be effective, choose the best course of therapy, or monitor therapies along the patient journey.
Alpha-aminoadipic acid – Metabolite of the month
Aminoadipic acid is an alpha amino acid, meaning its amino group is attached to the carbon atom in the alpha position. It’s a nonproteinogenic amino acid found in all eukaryotes.
Cell culture metabolomics – The shortcut to drug development
Cell culture metabolomics is an excellent tool to decrease drug development costs while increasing speed and success rate. Its applicability has been proven in numerous studies.
Metabolite of the month – Aminobutyric acids
Alpha-, beta- and gamma-aminobutyric acids (AABA, BABA and GABA) are a group of structurally similar nonproteinogenic amino acids.
Pan-cohort studies – The future of population health
With the second edition of this cohort event Pan-cohort studies – The future of population health- we are looking forward to expand into the physical spaces and stretch the scope beyond metabolomics.
WebIDQ the new evolution. Why the transition from MetIDQ?
During this webinar you can learn about WebIDQ, the next evolution of biocrates’ metabolomics workflow management and data processing software. With an intuitive user interface, WebIDQ guides users from sample registration through quantification and reporting.
Quantitative metabolomics database (QMDB)
During this webinar you can learn the benefits and possibilites of using the biocrates Quantitative metabolomics database (QMDB)
Histamine – Metabolite of the month
Histamine stimulates smooth muscle contraction, vasodilation, and gastric acid secretion, and plays a role in cell differentiation, proliferation and regeneration