A combination of various technologies in pharmacometabolomics enables biomarker discovery for prediction of drug responses of individual patients.
Pharmacometabolomics provides biomarkers for precision medicine
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Pharmacology
Distinct metabolic alterations in cancer- and chemotherapy-induced cachexia
Cancer in comparison to chemotherapy cause distinct metabolic perturbations, which both lead to the development and progression of cachexia characterized by extreme weight loss and muscle wasting.
Effect of proton pump inhibitor use on development of cardiovascular diseases
Population-based cohort study reveals link between proton pump inhibitor intake and increasing risk for cardiovascular events.
Metabolism of fatty liver disease and the impact of therapy
New study demonstrates the power of metabolomics in boosting our understanding of fatty liver disease – and possible treatments. Obeticholic acid reverses metabolic changes in NASH.
Could metabolites enhance pharmacological cancer treatments?
Metabolites in action: metabolomics reveals link between mitochondrial respiration and proteasomal degradation mechanisms, with important implications for cancer drugs.
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