Antibiotics influence the gut microbiome and the plasma or fecal metabolome depending on the class of antibiotics and the gut bacterial composition.
Are effects of antibiotics reflected in the metabolome?
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Pharmacology
Metabolic effects of anti-TNF α therapy
Anti-TNF α therapy in Crohn´s Disease improves liver steatosis through changes in gut bacteria and triglycerides.
Pharmacometabolomics provides biomarkers for precision medicine
A combination of various technologies in pharmacometabolomics enables biomarker discovery for prediction of drug responses of individual patients.
Distinct metabolic alterations in cancer- and chemotherapy-induced cachexia
Cancer in comparison to chemotherapy cause distinct metabolic perturbations, which both lead to the development and progression of cachexia characterized by extreme weight loss and muscle wasting.
Effect of proton pump inhibitor use on development of cardiovascular diseases
Population-based cohort study reveals link between proton pump inhibitor intake and increasing risk for cardiovascular events.