The metabolite of this month is cholic acid, of the the bile acid class. Notorious for their role in digestion, they are also powerful regulators of metabolism.
Cholic acid – a signaling molecule
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Microbiome
The microbiome is made of microorganisms living in and on our body. Through metabolism, the microbiome contributes essential metabolites that contribute to our health, but can also release toxic metabolites that contribute to disease. The study of the microbiome together with host biology is currently one of the hottest topics in biomedical research.
Bile acids and newborn’s gut microbiota maturation
The maturation of the newborn´s microbiome is critically dependent on bile acids from liver and can be manipulated by administration of bile acids in mice.
Elevated serum bile acid levels contribute to NASH-HCC
Higher serum bile acid levels and an altered gut microbiome contribute to fibrogenesis, liver injury, and tumorigenesis in cirrhotic and noncirrhotic NASH-HCC.
Gut microbiota and statins
Metabolomics and 16S rRNA profiling uncover the crosstalk between gut microbiota and statins efficacy that can hide behind inter-individual variability.
Best practices for feces metabolomics
biocrates enables reproducible quantitative metabolomics in fecal samples. Understand the challenges associated with this matrix.
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