Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at Isovaleric acid, a five-carbon branched ..
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The microbiome is made of microorganisms living in and on our body. Through metabolism, the microbiome contributes essential metabolites that contribute to our health, but can also release toxic metabolites that contribute to disease. The study of the microbiome together with host biology is currently one of the hottest topics in biomedical research.
Why you should combine analysis of short-chain fatty acids (SCFAs) and medium-chain fatty acids (MCFAs)
Short-chain fatty acids (SCFAs) and medium-chain fatty acids (MCFAs) are well-established as important diet-based energy sources.
Metabolite of the month – Butyric acid
Metabolite of the month is your sneak peek into the world of metabolomics. In this month´s article, we took a closer look at butyric acid, which is one of three common SCFAs in the human gut.
How bile salt hydrolases affect the gut microbiome
Bile acid composition and a complex network of bile salt hydrolases in the gut shape microbial colonization.
Modulating gut microbiota with prebiotics could control type 2 diabetes
Modulation of gut microbiota with prebiotic Fructooligosaccharides (FOS) led to discovery of two novel enterosynes (12-HETE and enkephalin), with potential to control type 2 diabetes
Giardia lamblia alters bile acid secretion in mice
A neonatal mouse model demonstrated that G. lamblia infection altered the composition of the gut microbiome and enhanced bile acid secretion and deconjugation.
Microbiome instability and host metabolic dysfunctions
Plasma metabolome and microbiota profiles from the SHIP cohort link microbiome instability to liver steatosis, diabetes mellitus, and pancreatic dysfunction
Cholic acid – a signaling molecule
The metabolite of this month is cholic acid, of the the bile acid class. Notorious for their role in digestion, they are also powerful regulators of metabolism.
Bile acids and newborn’s gut microbiota maturation
The maturation of the newborn´s microbiome is critically dependent on bile acids from liver and can be manipulated by administration of bile acids in mice.
Elevated serum bile acid levels contribute to NASH-HCC
Higher serum bile acid levels and an altered gut microbiome contribute to fibrogenesis, liver injury, and tumorigenesis in cirrhotic and noncirrhotic NASH-HCC.