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The microbiome is made of microorganisms living in and on our body. Through metabolism, the microbiome contributes essential metabolites that contribute to our health, but can also release toxic metabolites that contribute to disease. The study of the microbiome together with host biology is currently one of the hottest topics in biomedical research.
2025 was a year shaped by 5P medicine for biocrates. From the evolution of our scientific content to new product highlights and our integration into the Biognosys Group, this year demonstrated how metabolomics brings the five pillars of modern medicine – preventive, predictive, precision, population-based, and participatory – to life.
Homovanillic acid (HVA) is a monocarboxylic acid best known for its role as a major dopamine metabolite.
p-cresol glucuronide (pCG) is a liver-derived conjugate of the gut microbial metabolite p-cresol, excreted via the kidneys, and it reflects gut-microbiome activity in blood and urine.
Cyclic adenosine monophosphate (cAMP) is a universal second messenger which translates extracellular cues into cellular responses regulating metabolism, gene expression, neurobiology, and immunity. Dysregulated cAMP signaling contributes to cancer, inflammation, and neurological disorders, making it a key target in precision medicine.
Cancer cells rely on altered energy metabolism to fuel growth. See how metabolomics sheds light on these changes and their impact on tumor progression and therapy.