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Metabolites are essential for life. They are the products of the chemical processes that occur in the body and are necessary for the body to function. Metabolites can be used as biomarkers to diagnose disease and to assess treatment efficacy.
In this blog, we’ll take a closer look at one specific metabolite. Topics of discussion include the biosynthesis and degradation in a broader health context, and the effects of dysregulation in disease.
Fructose is a simple sugar found in fruits and honey, but also added to many processed foods. Unlike glucose, it is mainly metabolized in the liver, and excessive intake can contribute to metabolic and inflammatory health issues.
Homovanillic acid (HVA) is a monocarboxylic acid best known for its role as a major dopamine metabolite.
p-cresol glucuronide (pCG) is a liver-derived conjugate of the gut microbial metabolite p-cresol, excreted via the kidneys, and it reflects gut-microbiome activity in blood and urine.
Cyclic adenosine monophosphate (cAMP) is a universal second messenger which translates extracellular cues into cellular responses regulating metabolism, gene expression, neurobiology, and immunity. Dysregulated cAMP signaling contributes to cancer, inflammation, and neurological disorders, making it a key target in precision medicine.
Bilirubin reduces oxidative stress, supports liver and cardiovascular functions, and protects against inflammation-related health conditions.