Metabolites in action: metabolomics reveals link between mitochondrial respiration and proteasomal degradation mechanisms, with important implications for cancer drugs.
Could metabolites enhance pharmacological cancer treatments?
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Literature
Prenatal PFAS exposure leads to liver injuries in children
HELIX metabolomics study links prenatal PFAS (perfluoralkyl substances) exposure to metabolic origin of liver injuries in children.
Mechanism of gallstone formation
Chromatin mesh of specific immune cells aggregates bile crystals to gallstones and might constitute a promising pharmacological target against gallstone formation.
Modulating gut microbiota with prebiotics could control type 2 diabetes
Modulation of gut microbiota with prebiotic Fructooligosaccharides (FOS) led to discovery of two novel enterosynes (12-HETE and enkephalin), with potential to control type 2 diabetes
Commentary – A current view on steroid hormones
Although they are only present in low concentration in our bodies, steroid hormones play a crucial role in a variety of biological processes. This article reflects recent studies on the topic.