Explore how disruptions in peroxisomal lipid metabolism drive disease phenotypes and how lipidomics can reveal early biomarkers of rare disorders.
Peroxisome biogenesis disorders and the lipidome
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5P medicine
cAMP – a currency of cell signaling
Cyclic adenosine monophosphate (cAMP) is a universal second messenger which translates extracellular cues into cellular responses regulating metabolism, gene expression, neurobiology, and immunity. Dysregulated cAMP signaling contributes to cancer, inflammation, and neurological disorders, making it a key target in precision medicine.
Bilirubin – from waste pigment to regulatory metabolite
Bilirubin reduces oxidative stress, supports liver and cardiovascular functions, and protects against inflammation-related health conditions.
Itaconic acid – from immune defense to a target in chronic disease
Itaconic acid shapes immune responses, affects the gut microbiome, and may influence cardiovascular, neurological, metabolic, and cancer outcomes.
Participatory medicine – Transform medicine with metabolomics – part 5 of 5
In this five-part blog series, Alice Limonciel explores the role of metabolomics in 5P medicine. In this final article of our 5P medicine series, we explore how metabolomics empowers participatory medicine by enabling patients to collect meaningful health data from home.