Altered bile acid profile associates with cognitive impairment in Alzheimer's disease - An emerging role for gut microbiome
The understanding of health and disease in humans and other species is increasingly dependent on our understanding of the metabolic processes of our microbial lodgers. The large study at hand by Mahmoudian Dehkordi et al. makes that connection very clear. The authors found and confirmed associations between microbially produced secondary bile acids and the progression of cognitive decline in Alzheimer´s disease in a large cohort study. Additionally, previously measured genetic factors were included in the analysis so that a more comprehensive picture could be established. The conclusion was that plasma levels of secondary, microbially derived bile acids, such as deoxycholic acid, positively correlate with the leadup to Alzheimer´s disease progression. At the same time, plasma concentration of cholic acid, the precursor primary bile acid, shows a negative correlation. Together, this is in line with the presumable cytotoxic nature of elevated levels of secondary bile acids in plasma.
Siamak Mahmoudian Dehkordi, Matthias Arnold, Kwangsik Nho, Shahzad Ahmad, Wei Jia, Guoxiang Xie, Gregory Louie, Alexandra Kueider-Paisley, M. Arthur Moseley, J. Will Thompson, Lisa St John Williams, Jessica D. Tenenbaum, Colette Blach, Rebecca Baillie, Xianlin Han, Sudeepa Bhattacharyya, Jon B. Toledo, Simon Schafferer, Sebastian Klein, Therese Koal, Shannon L. Risacher, Mitchel Allan Kling, Alison Motsinger-Reif, Daniel M. Rotroff, John Jack, Thomas Hankemeier, David A. Bennett, Philip L. De Jager, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, P. Murali Doraiswamy, Cornelia M. van Duijn, Andrew J. Saykin, Gabi Kastenmüller, Rima Kaddurah-Daouk, Altered bile acid profile associates with cognitive impairment in Alzheimer's disease - An emerging role for gut microbiome. Alzheimer's & Dementia 2019, https://doi.org/10.1016/j.jalz.2018.07.217
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