Acylcarnitine assay

Understand energy homeostasis across generations

Acylcarnitines play a vital role in energy production and metabolism. Studying them can help us understand and diagnose inborn errors of metabolism and explore mechanisms of aging and age-related diseases. Acylcarnitines are the missing link between cellular malfunction and physiological outcome – a set of universal markers for energy homeostasis across generations.

Acylcarnitine assay

Understand energy homeostasis across generations

Acylcarnitines play an exceptional role in the understanding and diagnosis of inborn errors of metabolism. A growing body of evidence puts acylcarnitines now in the spotlight of uncovering mechanisms of aging and age-related diseases. Acylcarnitines and their regulation are the missing piece between cellular malfunction and physiological outcome – a set of universal markers for energy homeostasis across generations.

Comprehensive coverage

  • Increased acylcarnitine panel beyond usual clinical coverage to discover new markers 
  • Relevant metabolite sums and ratios to better understand enzyme activities and regulations
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Clinical applications

  • Novel applications in diseases such as cardiovascular disease and Alzheimer’s disease
  • Screening for inborn errors of metabolism
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Reliable and reproducible

  • Results can be combined with other biocrates kit or assay results to maximize insights
  • Comprehensive, quantitative data supports biomarkers and therapeutic target studies
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Understand the implications

  • Support in data interpretation available
  • Tools to translate metabolomics into knowledge
Look at the 44 acylcarnitines included in this assay
C0 Carnitine
C2 Acetylcarnitine
C3 Propionylcarnitine
C3-DC Malonylcarnitine
C3-DC-M Methylmalonylcarnitine
C4 Butyrylcarnitine
C4-2M 2-methylbutyrylcarnitine
C4-DC Succinylcarnitine
C4-OH Hydroxybutyrylcarnitine
C4:1-M 3-Methylcrotonylcarnitine
C5 Valerylcarnitine
C5-DC Glutarylcarnitine
C5-M-DC Methylglutarylcarnitine
C5:1 Tiglylcarnitine
C6 Hexanoylcarnitine
C6-DC Adipoylcarnitine
C6-OH Hydroxyhexanoylcarnitine
C8 Octanoylcarnitine
C8-DC Suberoylcarnitine
trans -2-C8:1 Octenoylcarnitine
C10 Decanoylcarnitine
C10-DC Sebacoylcarnitine
trans-2-C10:1 Decenoylcarnitine
C12 Dodecanoylcarnitine
C12-OH Hydroxydodecanoylcarnitine
trans -2-C12:1 Dodecenoylcarnitine
C14 Tetradecanoylcarnitine
trans -2-C14:1 Tetradecenoylcarnitine
C14:2 Tetradecadienylcarnitine
C16 Hexadecanoylcarnitine
C16-OH Hydroxyhexadecanoylcarnitine
trans -2-C16:1 Hexadecenoylcarnitine
C16:1-OH Hydroxyhexadecenoylcarnitine
C18 Octadecanoylcarnitine
C18-OH Hydroxyoctadecanoylcarnitine
cis-9-C18:1 cis-9-Octadecenoylcarnitine
C18:1-OH Hydroxyoctadecenoylcarnitine
C18:2 Octadecadienylcarnitine
C20:4 Arachidonoylcarnitine
Iso-C5 Isovalerylcarnitine
Iso-C4 Isobutyrylcarnitine
C5-P Pivaloylcarnitine
C5OH-I Hydroxyisovalerylcarnitine
cis-9-C16:1 cis-9-hexadecenoylcarnitine

Acylcarnitines in health and disease

Analysis of acylcarnitines is a go-to check when screening blood for inborn errors of metabolism. There is also growing interest in how acylcarnitines can help to understand and diagnose other metabolic diseases, such as certain types of cancer, cardiovascular diseases and neurological disorders.

Many diseases are associated with changes in acylcarnitine metabolism

  • Alzheimer´s disease
  • Depression
  • Hepatocellular cancer
  • Cardiovascular disease
  • Liver disease (NASH)
  • Newborn screening

 

Role of acylcarnitines in cellular and systemic metabolism

Acylcarnitines’ role in both, glucose and fatty acid metabolism

  • Regulate beta-oxidation
  • Maintain the balance between beta-oxidation and glucose oxidation
  • Involved in metabolism of branched chain amino acids (BCAA)
  • Involved in production of ketone bodies
acylcarnitine pathways

How to read mitochondrial metabolism from plasma.

Mammals get fatty acids through their diet, when fat is broken down during digestion. Albumin transports fatty acids to cells, where they conjugate with Coenzyme A to form Acyl-CoA. Acyl-CoA can either be used in beta-oxidation inside mitochondria or, depending on the current metabolic situation and mitochondrial status, conjugated with carnitine to form acylcarnitine. Excess acylcarnitines are released into the bloodstream, acting as a regulator of glucose metabolism.

More Resources

biocrates blog articles and insights from the literature

Metabolite of the month – Carnitine
carnitine facts

Metabolite of the month is your sneak peek into the world of metabolomics. This month we look at carnitine #loveyourmetabolites

The metabolic cost of a marathon: fitness matters

Slightly out of focus picture of the legs of marathon runners

Targeted metabolomics reveals differences in metabolic profiles between top athletes and amateur runners days after running a marathon.

Is Alzheimer´s a metabolic disease?

Memory-loss-Aug-27-2019

Alzheimer’s disease (AD) has many facets. Metabolomics supports Alzheimer’s early diagnosis and research on the treatment of AD.

Relevant Literature

For research use only | not for use in diagnostic procedures.