Acylcarnitine assay

Uncover mechanisms of aging, cancer and cardiovascular diseases

Acylcarnitines play a vital role in energy production and metabolism. Studying them can help us understand and diagnose inborn errors of metabolism and explore mechanisms of aging and age-related diseases. Acylcarnitines are the missing link between cellular malfunction and physiological outcome – a set of universal markers for energy homeostasis across generations.

Acylcarnitine assay

Understand energy homeostasis across generations

Acylcarnitines play an exceptional role in the understanding and diagnosis of inborn errors of metabolism. A growing body of evidence puts acylcarnitines now in the spotlight of uncovering mechanisms of aging and age-related diseases. Acylcarnitines and their regulation are the missing piece between cellular malfunction and physiological outcome – a set of universal markers for energy homeostasis across generations.

Comprehensive coverage

  • Increased acylcarnitine panel beyond usual clinical coverage to discover new markers 
  • Relevant metabolite sums and ratios to better understand enzyme activities and regulations

Clinical applications

  • Novel applications in diseases such as cardiovascular disease and Alzheimer’s disease
  • Screening for inborn errors of metabolism

Reliable and reproducible

  • Results can be combined with other biocrates kit or assay results to maximize insights
  • Comprehensive, quantitative data supports biomarkers and therapeutic target studies

Understand the implications

  • Support in data interpretation available
  • Tools to translate metabolomics into knowledge
Look at the 44 acylcarnitines included in this assay
C0Carnitine
C2Acetylcarnitine
C3Propionylcarnitine
C3-DCMalonylcarnitine
C3-DC-MMethylmalonylcarnitine
C4Butyrylcarnitine
C4-2M2-methylbutyrylcarnitine
C4-DCSuccinylcarnitine
C4-OHHydroxybutyrylcarnitine
C4:1-M3-Methylcrotonylcarnitine
C5Valerylcarnitine
C5-DCGlutarylcarnitine
C5-M-DCMethylglutarylcarnitine
C5:1Tiglylcarnitine
C6Hexanoylcarnitine
C6-DCAdipoylcarnitine
C6-OHHydroxyhexanoylcarnitine
C8Octanoylcarnitine
C8-DCSubarylcarnitine
trans -2-C8:1Octenoylcarnitine
C10Decanoylcarnitine
C10-DCSebarylcarnitine
trans-2-C10:1Decenoylcarnitine
C12Dodecanoylcarnitine
C12-OHHydroxydodecanoylcarnitine
trans -2-C12:1Dodecenoylcarnitine
C14Tetradecanoylcarnitine
trans -2-C14:1Tetradecenoylcarnitine
C14:2Tetradecadienylcarnitine
C16Hexadecanoylcarnitine
C16-OHHydroxyhexadecanoylcarnitine
trans -2-C16:1Hexadecenoylcarnitine
C16:1-OHHydroxyhexadecenoylcarnitine
C18Octadecanoylcarnitine
C18-OHHydroxyoctadecanoylcarnitine
cis-9-C18:1cis-9-Octadecenoylcarnitine
C18:1-OHHydroxyoctadecenoylcarnitine
C18:2Octadecadienylcarnitine
C20:4Arachidonoylcarnitine
Iso-C5Isovalerylcarnitine
Iso-C4Isobutyrylcarnitine
C5-PPivaloylcarnitine
C5OH-IHydroxyisovalerylcarnitine
cis-9-C16:1cis-9-hexadecenoylcarnitine

Acylcarnitines in health and disease

Analysis of acylcarnitines is a go-to check when screening blood for inborn errors of metabolism. There is also growing interest in how acylcarnitines can help to understand and diagnose other metabolic diseases, such as certain types of cancer, cardiovascular diseases and neurological disorders.

Many diseases are associated with changes in acylcarnitine metabolism

  • Alzheimer´s disease
  • Depression
  • Hepatocellular cancer
  • Cardiovascular disease
  • Liver disease (NASH)
  • Newborn screening

 

Role of acylcarnitines in cellular and systemic metabolism

Acylcarnitines’ role in both, glucose and fatty acid metabolism

  • Regulate beta-oxidation
  • Maintain the balance between beta-oxidation and glucose oxidation
  • Involved in metabolism of branched chain amino acids (BCAA)
  • Involved in production of ketone bodies

How to read mitochondrial metabolism from plasma.

Mammals get fatty acids through their diet, when fat is broken down during digestion. Albumin transports fatty acids to cells, where they conjugate with Coenzyme A to form Acyl-CoA. Acyl-CoA can either be used in beta-oxidation inside mitochondria or, depending on the current metabolic situation and mitochondrial status, conjugated with carnitine to form acylcarnitine. Excess acylcarnitines are released into the bloodstream, acting as a regulator of glucose metabolism.

More Resources

biocrates blog articles and insights from the literature

Metabolite of the month – Carnitine

Metabolite of the month is your sneak peek into the world of metabolomics. This month we look at carnitine #loveyourmetabolites

The metabolic cost of a marathon: fitness matters

Targeted metabolomics reveals differences in metabolic profiles between top athletes and amateur runners days after running a marathon.

Is Alzheimer´s a metabolic disease?

Alzheimer’s disease (AD) has many facets. Metabolomics supports Alzheimer’s early diagnosis and research on the treatment of AD.

Relevant Literature

For research use only | not for use in diagnostic procedures.