Alterations in circulating amino acid metabolite ratio associated with arginase activity are potential indicators of metabolic syndrome: the korean genome and epidemiology study
Understanding biochemical pathways is one of the great challenges of science today. Due to growing interest in arginine metabolism and its availability in conditions such as diabetes, cardiovascular risk, and obesity, Moon et al. correlate diverse intermediate metabolites to the mentioned conditions. While arginine bioavailability (defined as arginine/(ornithine + citrulline)) negatively correlates with signs of metabolic syndrome, the ornithine/citrulline ratio positively correlates with signs of metabolic syndrome. Key to these insights into enzymatic pathways is not only the absolute amounts of metabolites, but also to take sums and ratios among metabolite concentrations.
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Jiyoung Moon, Oh Yoen Kim, Garam Jo and Min-Jeong Shin: Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study. (2017) Nutrients | DOI: 10.3390/nu9070740