Our technology
The gold standard in targeted metabolomics
Metabolomics is a powerful tool to answer the multidimensional questions of biology. From just a few microliters of sample, the phenotype of an individual can be uncovered and explored. Metabolomics is key to generating high-quality and reliable data that is mandatory for today’s biological research and individualized health.
The gold standard in quantitative metabolomics
Metabolomics is a powerful tool to answer the multidimensional questions of biology. From just a few microliters of sample, the phenotype of an individual can be uncovered and explored. Metabolomics is key to generating high-quality and reliable data that is mandatory for today’s biological research and individualized health.
The central theme of biocrates’ metabolomics profiling products is providing quantitative, reproducible assays designed in an easy and ready-to-use kit format. Quantitative, standardized and quality-controlled methods combined with a standardized format guarantee robust and reproducible results – the cornerstones of any scientific finding.
biocrates kits in your laboratory
We democratize metabolomics
– All-in-one metabolomics and lipidomics solution
– Ready to use and easy to measure
– Accessible advanced analysis
– Peace of mind with automated quality checks and guided expert support
Work smarter – not harder
– 1,400+ analytically validated biomarkers [µM] in a single assay
– Robust, reproducible, scalable, time and resource saving
– Global integration into laboratory network by cloud-based solutions
– Cost per analyte that is meeting all budgets
Get metabolomics done right
– Broad compatibility with data analysis tools
– FAIR compliant with complete ownership of data
– Data security and GDPR compliant
– Benchmark against QMDB reference database
Standardized workflow
biocrates’ kits include years of experience in targeted metabolomics. These ready-to-use kits deliver quality-controlled and reproducible quantification of metabolites in biological samples by following only five steps. WebIDQ, a user-friendly workflow manager software, guides the user through the whole process, from sample registration to biological interpretation of the results.
- Perform system suitability test
- Derivatize and extract your samples
- Pipette samples, standards, and QCs onto the plate
Sample preparation (wet work only here)
- Perform system suitability test
- Derivatize and extract your samples
- Pipette samples, standards, and QCs onto the plate
Data collection
- Run plates with LC- and FIA-MS
- Instrument-specific methods are provided
Quantitation & Validation
- Automated peak identification and quantification
- Automated sensitivity and accuracy check
- In-built data normalization suite
Statistics & Interpretation
- Perform advanced statistics with MetIDQ™ StatPack OR
- Export from MetIDQ™ to your statistics software of choice
- For MxP® Quant 500: support your data interpretation with the innovative MetaboINDICATOR™ add-on to MetIDQ™.
Insight &Understanding
- Make decisions based on standardized and reproducible metabolomic data
- Compare your results with published kit data from other laboratories
Peace of mind
We’ve taken care of the technical details so that you can focus on the science. Spend more time discovering biological implications and planning for your next challenges to tackle.
Metabolomics kit products
MxP® Quant 500 XL
The largest combination of lipids and small molecules for quantitative metabolic profiling in a single kit
MxP® Quant 500
The comprehensive kit to study mechanisms of disease, nutrition, and the microbiome
AbsoluteIDQ® p400 HR
The high performance, high resolution tool for targeted metabolomics profiling
AbsoluteIDQ® p180
The gold standard in quantitative metabolomics for all fields of research
AbsoluteIDQ® Bile acids
The benchmark solution to assess host-microbiota interaction
SMartIDQ® alpha kit
Meaningful metabolite coverage for high-throughput needs
What is in a kit?
The plate
biocrates’ kits are designed for high throughput experiments in a standard 96 well plate format allowing up to 82 user samples per plate. To accommodate users with smaller sample sizes, half sized and training plates are also available. The plates incorporate a novel insert design allowing all preparation and cleanup to be performed directly on the plate. A top filter plate is incorporated to remove proteins that precipitate during preparation. Our proprietary design allows for more efficient drying and extraction improving the quality of results. At the end of preparation, samples are collected in the bottom 96-well plate which can be run directly in your LC-MS autosampler.
Components
biocrates kits are equipped with all of the required components for a robust, quantitative analysis. For quantification, seven levels of calibration standards and isotope-labeled internal standards are used. For performance validation and data normalization, plasma-based quality control samples at three concentration levels are provided and directly incorporated with our software. All reagents come as lyophilized solids in color-coded vials for quick resuspension and easy preparation.
Methods
Each of our kits has been developed and validated for specific LC-MS systems from a number of vendors. We carefully tailor and optimize each method to provide the best possible performance for every instrument. The kits include all vendor-specific acquisition methods. This includes MRM transitions, ion source parameters and chromatography settings to make setup quick and easy without the need for extensive method development. After data collection, processing methods are also provided to make data processing quick and robust. Data processing and validation are directly incorporated with biocrates’ MetIDQ software.
Matrices and sample preparation
While specifically validated for plasma and serum samples, our kits can be used for any samples containing endogenous metabolites. We have developed substantial experience over the years in sample preparation and matrix use.
We offer guidelines on the preparation of blood samples as well as application notes on the preparation of fecal or urine samples and many more. Contact our support in case you have questions on sample preparation or non-standard matrices.
WebIDQ software
WebIDQ is the next evolution of biocrates’ metabolomics workflow management and data processing software. With an intuitive user interface, WebIDQ guides users from sample registration through quantification and reporting.
Building on the proven functionality of MetIDQ software, WebIDQ is designed specifically for a cloud environment making data analysis efficient from every device. New features such as automated peak picking and MetaboINDICATOR extensions make this software the go-to companion for quantitative metabolomics.
A WebIDQ subscription is needed to run biocrates kits and to process kit-generated data.
“Our Metabolomics Core is involved in many long-term projects. Such projects require the generation of reliable and comparable data over a long period of time, so data quality is of paramount importance to us. We rely on the biocrates platform’s high-quality workflow and data analysis pipeline, which helped us eliminate variability and generate reproducible data. Their technology has also proven to be highly versatile and we could generate amazing insights in different indications using a wide spectrum of sample matrices (e.g. biofluids, tissues, cells). Therefore, I highly recommend the biocrates platform to any researcher looking to improve their data quality or just getting started in metabolomics.”
Related assets
brochure
WebIDQ software
pdf ~ 2 MB
download
brochure
MxP Quant 500 XL kit
pdf ~ 2 MB
download
brochure
biocrates kit technology
pdf ~ 6 MB
download
brochure
biocrates services
pdf ~ 1,5 MB
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Talk to an expert
biocrates life sciences ag
Eduard-Bodem-Gasse 8
6020 Innsbruck | AUSTRIA
Phone +43 512 579823
Fax +43 512 579823-329
biocrates inc.
26895 Aliso Creek Rd Ste B-426
Aliso Viejo, CA 92656-5301
Phone +1 774 424 8150
Operating hours: Mo – Fr | 9 am – 7 pm (EST)