MxP^®Quant 500 XL kit

MxP® Quant 500 XL

Unraveling the complexity of disease

The MxP^® Quant 500 XL offers the largest combination of lipids and metabolites for targeted metabolic profiling in a single kit. Powered by biocrates’ standardized, quality-controlled, and reproducible metabolomics technology, the ready-to-use kit covers more than 1,000 compounds from various biochemical classes. With more than 400 quantifiable metabolism indicators, covering hundreds of metabolic pathways, researchers will be equipped with the right solution for a more comprehensive understanding of health and disease.

Quantitative metabolomics kit for analysis of more than 1400 biomarkers with all components, plates, standards

Unraveling the complexity of disease

The MxP^® Quant 500 XL offers the largest combination of lipids and small molecules for quantitative metabolomics profiling in a single kit. Powered by biocrates’ standardized, quality-controlled, and reproducible metabolomics technology, the ready-to-use kit covers more than 1,000 metabolites from various biochemical classes. With more than 400 quantifiable metabolism indicators, covering hundreds of metabolic pathways, researchers will be equipped with the right solution for a more comprehensive understanding of health and disease.

Application note

Extensive pathway coverage

Quantifies up to 1,019 metabolites from 39 biochemical classes from minimal sample amounts
Enables study hundreds of relevant pathways with over 400 metabolism indicators
Provides a profound functional understanding of lipid and metabolite homeostasis

Deciphering disease complexity

Includes hundreds of metabolites related to healthy aging and neurodegenerative diseases
Expands coverage of cardiometabolic diseases including metabolism of non-alcoholic fatty liver (NAFLD) and cardiovascular disease (CVD)

Easy and ready-to-use

Complete workflow from sample registration to data generation
No need for method development or optimization
Requires only 20 µL sample volume, applicable to various matrices

Quantitative and reproducible

Quantification based on internal standards and calibration curves
Standardized, quality controlled, and optimized for longitudinal studies
Proven high accuracy and reproducibility through cross-lab validation

Kit components

Standards and consumables

Patented 96-well filter plates with pre-set internal standards
Calibration standards and quality controls
Test samples for system suitability test

Methods and protocols

Quick-start guide and user manual
Sample preparation protocol
Instrument-specific methods

Kit requirements

WebIDQ™ – Workflow manager

Cloud-based software (on-premise option also available)
Complete experimental process guidance
Automated quantification, technical validation and report generation
MetaboINDICATOR™ with more than 400 biologically relevant metabolite sums and ratios

LC column and MS systems

Compatible with Agilent 6495 C, SCIEX 5500, 5500+, and Waters TQ-XS
Validated column system
Compatible with ultra high performance liquid chromatography (UHPLC)

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Quantitative analysis of up to 1,019 metabolites from 39 biochemical classes

Metabolite coverage

Small molecules

Alkaloids (1)
Amine oxides (1)
Amino acids (20)
Amino acid related (30)
Bile acids (14)
Biogenic amines (9)
Carbohydrates and related (1)
Carboxylic acids (7)
Cresols (1)
Fatty acids – Free/non-covalently bound (12)
Hormones and related (4)
Indoles and derivatives (4)
Nucleobases and related (2)
Vitamins and cofactors (1)

Polar lipids

Acylcarnitines (40)
Phosphatidic acids (41)
Lysophosphatidic acids (8)
Phosphatidylcholines (76)
Lysophosphatidylcholines (14)
Phosphatidylethanolamines (95)
Lysophosphatidylethanolamines (43)
Phosphatidylglycerols (64)
Lysophophatidylglycerols (10)
Phosphatidylinositols (53)
Lysophosphatidylinositols (16)
Phosphatidylserines (18)
Lysophosphatidylserines (12)
Sphinganines and sphingosines (8)
Sphinganine and sphingosine phosphates (8)
Sphingomyelins (15)
Ceramides (29)
Dihydroceramides (8)
Hexosylceramides (19)
Dihexosylceramides (9)
Trihexosylceramides (6)

Neutral lipids

Cholesteryl esters (22)
Monoglycerides (12)
Diglycerides (44)
Triglycerides (242)

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MetaboINDICATOR™ – MxP® Quant 500 XL kit

Translate metabolomics into knowledge with one click

Calculating and understanding metabolite sums and ratios makes your biological data interpretation easier and more comprehensive. That is why we created MetaboINDICATOR™ as an add-on tool to WebIDQ. With one click you can find out how metabolite sums and ratios are associated with related biological functions so your data has meaningful impact.

MetaboINDICATOR™ is more than an additional dimension to your data analysis; it unravels the scientiﬁc context behind your data. All in one click.

More about MetaboINDICATOR

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“Our institute was looking for a standardized and validated approach to further expand our metabolomics portfolio. In general, LC-MS-based methods lack comparability and robustness. In addition, most self-developed or commercially available targeted approaches do not cover a broad spectrum of metabolites. Therefore, we use the MxP® Quant 500 XL kit on a routine base as a certified lab, because it is the most comprehensive solution for quantitative results on small molecules and lipids and complementary to our NMR-based metabolomics panel.”

Dr. Sven Schuchardt

Head of Bio- and Environmental Analytics, Fraunhofer ITEM - Institute of Toxicology and Experimental Medicine, Hannover, Germany