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A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease.

Goffredo et al., 2017


A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Liu et al., 2017

A Predictive Metabolic Signature for the Transition from Gestational Diabetes to Type 2 Diabetes

Allalou et al., 2016

A single night of sleep curtailment increases plasma acylcarnitines: novel insights in the relationship between sleep and insulin resistance

Van den Berg et al., 2015

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

Geurts et al., 2015

Alterations in Circulating Amino Acid Metabolite Ratio Associated with Arginase Activity Are Potential Indicators of Metabolic Syndrome: The Korean Genome and Epidemiology Study.

Moon et al., 2017


Alterations in Human Liver Metabolome during Prolonged Cryostorage

Abuja et al., 2015

Alterations of the Lipid Metabolome in Dairy Cows Experiencing Excessive Lipolysis Early Postpartum

Humer et al., 2016

Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes

Wittenbecher et al., 2015

Antiandrogenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction

Zwadlo et al., 2015

Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease

Nkuipou-Kenfack et al., 2014

Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status.

Allam-Ndoul et al., 2016

Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype

Kim et al., 2016

Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort

Breitner et al., 2016

Associations between branched chain amino acid levels, obesity and cardiometabolic complications

Allam-Ndoul et al., 2015

Attenuation of Postoperative Acute Liver Failure by Mesenchymal Stem Cell Treatment Due to Metabolic Implications

Tautenhahn et al., 2015

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus

Hegade, Vinod S.; Pechlivanis, Alexandros; McDonald, Julie A. K.; Rees, Douglas; Corrigan, Margaret; Hirschfield, Gideon M.; Taylor-Robinson, Simon D.; Holmes, Elaine; Marchesi, Julian R.; Kendrick, Stuart; Jones, David E.

Liver international : official journal of the International Association for the Study of the Liver. 2019; 39 (5):967–975

Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice

Franko et al., 2016

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

Mouzaki et al., 2016

Bioinformatics analysis of targeted metabolomics--uncovering old and new tales of diabetic mice under medication

Altmaier, Elisabeth; Ramsay, Steven L.; Graber, Armin; Mewes, Hans-Werner; Weinberger, Klaus M.; Suhre, Karsten

Endocrinology (Endocrinology) 2008; 149 (7):3478–3489.

BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries.

Zeller et al., 2014

Blood, urine and faecal metabolite profiles in the study of adult renal disease

Barrios et al., 2015

Cardiovascular Risk Factors Associated with Blood Metabolite Concentrations and Their Alterations over a 4-Year Period in a Population-Based Cohort

Lacruz et al., 2016

Circulation: Cardiovascular Genetics

Changes in metabolite profiles caused by genetically determined obesity in mice

Schäfer et al., 2014

Changes in the serum metabolite profile in obese children with weight loss

Reinehr et al., 2014

Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis.

Bothe et al., 2017

J Toxicol Sci.

Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver

Lehmann et al., 2013

Diabetes Care 2013, 36 (8), 2331–2338.

Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver

Feldman et al., 2016

Comparative Analysis and Modeling of the Severity of Steatohepatitis in DDC-Treated Mouse Strains

Pandey et al., 2014

Deletion of mouse Alkbh7 leads to obesity

Solberg et al., 2013

J Mol Cell Biol 2013, 5 (3), 194–203.

Detecting Renal Allograft Inflammation Using Quantitative Urine Metabolomics and CXCL10

Ho et al., 2016

Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites

Klöting et al., 2015

Diagnosing Fatty Liver Disease: A Comparative Evaluation of Metabolic Markers, Phenotypes, Genotypes and Established Biomarkers

Siegert et al., 2013

PLoS ONE 2013, 8 (10), e76813.

Differences in metabolomic and transcriptomic profiles between responders and non-responders to an n-3 polyunsaturated fatty acids

Rudkowska et al., 2013

Genes Nutr 2013, 8 (4), 411–423.

Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance

Ferrannini et al., 2013

Diabetes 2013, 62 (5), 1730–1737.

Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice.

Schnackenberg et al., 2016

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes

Xu et al., 2015

Effects of multiple ascending doses of the glucagon receptor antagonist, PF-06291874, in patients with type 2 diabetes mellitus

Kazierad et al., 2016

Endothelin-1 Overexpression Improves Renal Function in eNOS Knockout Mice

Tsuprykov et al., 2015

Enzymatically Modified Starch Ameliorates Postprandial Serum Triglycerides and Lipid Metabolome in Growing Pigs

Metzler-Zebeli et al., 2015

Evaluation of emerging biomarkers for major organ toxicities and disease states

Ellinger-Ziegelbauer, H. C.; Hellmund, M.; Pavkovic, M.; Petzuch, B.; Raschke, M.; Riefke, B.; Slopianka, M.

Toxicology letters. 2018; 295 :S42

Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study.

Jacobs et al., 2014

Experimental Glomerular Endothelial Injury In Vivo

Haddad et al., 2013

PLoS ONE 2013, 8 (10), e78244.

Exploring the Links between Diet and Health in an Irish Cohort: A Lipidomic Approach

O'Gorman et al., 2017

Journal of Proteome Research

Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.

Jäger et al., 2017

Scientific Reports

Genetically engineered pig models for diabetes research

Wolf et al., 2014

Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium

Kiermayer et al., 2015

High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice.

Kahle et al., 2015

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach

Floegel et al., 2013

Diabetes 2013, 62 (2), 639–648.

Immediate reduction of serum citrulline but no change of steroid profile after ini tiation of metformin in individuals with type 2 diabetes.

Breier et al., 2017

J Steroid Biochem Mol Biol.

Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase

Aumailley et al., 2015

Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition

Zhang et al., 2016

Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats.

Anzai et al., 2017

Scientific Reports

Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome.

Sung et al., 2016


Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers

Ward-Caviness et al., 2017


Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up

Mook et al., 2014

Increased urine acylcarnitines in diabetic ApoE-/- mice: Hydroxytetradecadienoylcarnitine (C14:2-OH) reflects diabetic nephropathy in a context of hyperlipidemia

Mirzoyan et al., 2017

Biochemical and Biophysical Research Communications

Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models

Renner et al., 2015

Integrative 1H-NMR-based Metabolomic Profiling to Identify Type-2 Diabetes Biomarkers: An Application to a Population of Qatar

Shahzad & Ullah, 2015

Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis.

Paapstel et al., 2017

Nutr Metab Cardiovasc Dis.

Lactation is associated with altered metabolomic signatures in women with gestational diabetes

Much et al., 2016

Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother–child cohort in Crete, Greece

Perng et al., 2016

Obesity Science & Practice

Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels

Binder et al., 2013

PLoS ONE 2013, 8 (9), e74705.

Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study

Floegel et al., 2014

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse

Vehmas et al., 2015

Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation

Cheema et al., 2014

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

Bonhoure et al., 2015

Maternal cytokine status may prime the metabolic profile and increase risk for obesity in children

Englich et al., 2017

International Journal of Obesity

Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Aumailley et al., 2015

Metabolic disturbances identified in plasma are associated with outcomes in patients with heart failure: diagnostic and prognostic value of metabolomics

Cheng et al., 2015

Metabolic Disturbances Identified in Plasma Samples from ST-Segment Elevation Myocardial Infarction Patients

Goulart, Vânia Aparecida Mendes; Santos, Anderson Kenedy; Sandrim, Valéria Cristina; Batista, Josimar Marques; Pinto, Mauro Cunha Xavier; Cameron, Luiz Cláudio; Resende, Rodrigo Ribeiro

Disease Markers. 2019; 2019 (4):1–10

Metabolic profile provides prognostic value better than galectin-3 in patients with heart failure

Wang et al., 2017

Journal of Cardiology

Metabolic Profiles during an Oral Glucose Tolerance Test in Pregnant Women with and without Gestational Diabetes

Lehmann et al., 2015

Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines

Chao de la Barca et al., 2016

Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals

Böhm et al., 2014

Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis

Halama et al., 2015

Metabolite profiles in heart failure: looking for unique signatures in a heterogeneous syndrome.

Wang & Gupta, 2015

Metabolites associate with kidney function decline and incident chronic kidney disease in the general population

Goek et al., 2013

Nephrol. Dial. Transplant. 2013, 28 (8), 2131–2138.

Metabolomic biomarkers correlating with hepatic lipidosis in dairy cows

Imhasly et al., 2014

Metabolomic Biomarkers for Obesity in Humans

Rauschert et al., 2014

Metabolomic Characteristics of Fatty Pancreas

Jaghutriz, Benjamin Assad; Wagner, Róbert; Heni, Martin; Lehmann, Rainer; Machann, Jürgen; Stefan, Norbert; Häring, Hans-Ulrich; Fritsche, Andreas

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2019;

Metabolomic distinction of microvascular effects of lipoprotein apheresis e A pilot study

Reimann et al., 2013

Atheroscler Suppl 2013, 14 (1)

Metabolomic fingerprint of heart failure with preserved ejection fraction

Zordoky et al., 2015

Metabolomic prediction of fetal congenital heart defect in the first trimester

Bahado-Singh et al., 2014

Metabolomic profiles of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients

Paapstel et al., 2016

Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism

Stechemesser et al., 2016

Molecular Metabolism

Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism.

Stechemesser et al., 2017

Molecular Metabolism

Metabolomic profiling in patients undergoing Off-Pump or On-Pump coronary artery bypass surgery

Kirov et al., 2017

BMC Cardiovascular Disorders

Metabolomic profiling of ascending thoracic aortic aneurysms and dissections - Implications for pathophysiology and biomarker discovery

Doppler et al., 2017


Metabolomic signature of Coronary Artery Disease in Type 2 Diabetes Mellitus

Stratmann et al., 2016

Metabolomic signature of Coronary Artery Disease in Type 2 Diabetes Mellitus.

Stratmann et al., 2017

International Journal of Endocrinology

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study.

Liu et al., 2017


Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function

Sandlers et al., 2016

Metabolomics reveals the sex-specific effects of the SORT1 low-density lipoprotein cholesterol locus in healthy young adults

Klein et al., 2014

Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels

Dahlhoff et al., 2014

Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice

Ryan et al., 2017


Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring

Renner, Simone; Martins, Ana Sofia; Streckel, Elisabeth; Braun-Reichhart, Christina; Backman, Mattias; Prehn, Cornelia; Klymiuk, Nikolai; Bähr, Andrea; Blutke, Andreas; Landbrecht-Schessl, Christina; Wünsch, Annegret; Kessler, Barbara; Kurome, Mayuko; Hinrichs, Arne; Koopmans, Sietse-Jan; Krebs, Stefan; Kemter, Elisabeth; Rathkolb, Birgit; Nagashima, Hiroshi; Blum, Helmut; Ritzmann, Mathias; Wanke, Rüdiger; Aigner, Bernhard; Adamski, Jerzy; Hrabe de Angelis, Martin; Wolf, Eckhard

Disease models & mechanisms. 2019;

Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis

Schröder et al., 2016

Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition

Nikolaeva et al., 2016

Oxidative stress in hypobaric hypoxia and influence on vessel-tone modifying mediators

Pichler et al., 2013

High Alt. Med. Biol. 2013, 14 (3), 273–279.

Percutaneous Closure of Left Atrial Appendage significantly affects Lipidome Metabolism

Yücel, G.; Behnes, M.; Barth, C.; Wenke, A.; Sartorius, B.; Mashayekhi, K.; Yazdani, B.; Bertsch, T.; Rusnak, J.; Saleh, A.; Hoffmann, U.; Fastner, C.; Lang, S.; Zhou, X.; Sattler, K.; Borggrefe, M.; Akin, I.

Scientific reports

Plasma and urinary amino acid metabolomic profiling in patients with different levels of kidney function

Duranton et al., 2014

Plasma Metabolomics reveal Alterations of Sphingo- and Glycerophospholipid Levels in Non-Diabetic Carriers of the Transcription Factor 7-Like 2 Polymorphism rs7903146

Then et al., 2013

PLoS ONE 2013, 8 (10), e78430.

Postpartum outcomes in women with gestational diabetes and their offspring: POGO study design and first-year results

Hummel et al., 2013

Prognostic clinical and molecular biomarkers of renal disease in type 2 diabetes

Pena et al., 2015

Rapid Growth and Childhood Obesity Are Strongly Associated with LysoPC(14

Rzehak et al., 2014

Relationship between the lipidome, inflammatory markers and insulin resistance

Wallace et al., 2014

Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals

Gao et al., 2016

Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts.

Floegel et al., 2017

Eur. J. Epidemiol

Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus

Pena et al., 2016

Serum metabolites related to cardiorespiratory fitness, physical activity energy expenditure, sedentary time and vigorous activity

Wientzek et al., 2014

Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women

Merz et al., 2016

Specific metabolic profiles and their relationship to insulin resistance in recent-onset type-1 and type-2 diabetes

Knebel et al., 2016

Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children

Bhattacharyya et al., 2014

The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults

Deschamps et al., 2015

The Hoorn Diabetes Care System (DCS) cohort. A prospective cohort of persons with type 2 diabetes treated in primary care in the Netherlands

van der Hejden et al., 2017

BMJ Open

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.

Blutke et al., 2017

Molecular Metabolism

Treatment with beta-blockers is associated with lower levels of Lp-PLA2 and suPAR in carotid plaques

Asciutto et al., 2013

Cardiovasc. Pathol. 2013, 22 (6), 438–443.

Tryptophan as a Surrogate Prognostic Marker for Diabetic Nephropathy.

Chou et al., 2017

J Diabetes Investig.

Twenty-four-hour rhythmicity of circulating metabolites: effect of body mass and type 2 diabetes

Isherwood et al., 2017

FASEB Journal

Type 2 diabetes is associated with postprandial amino acid measures

Mook-Kanamori et al., 2015

Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children

Hellmuth et al., 2015

Uncovering Factors Related to Pancreatic Beta-Cell Function

Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study

Niewczas et al., 2014

Urinary Metabolomics for Noninvasive Detection of Antibody-Mediated Rejection in Children After Kidney Transplantation.

Blydt-Hansen et al., 2017


Urinary Metabolomics for Noninvasive Detection of Borderline and Acute T Cell-Mediated Rejection in Children After Kidney Transplantation

Blydt-Hansen et al., 2014

Urine and plasma metabolites predict the development of diabetic nephropathy in individuals with Type 2 diabetes mellitus

Pena et al., 2014

Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam

Floegel et al., 2013

Eur J Clin Nutr 2013, 67 (10), 1100–1108.
Total items found: 128
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