Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation
Two of the widely accepted hallmarks of cancer are genetic mutations and metabolic deregulation. By integrating transcriptome, proteome, and metabolome data, a link between these two indicators has been discovered by Dalton and colleagues from Johns Hopkins University. Mutations in the spliceosome gene SF3B1 result in incorrect mRNA splicing and thus downregulation of several hundred genes and proteins predominantly involved in energy metabolism. Some of these downregulated proteins are of the mitochondrial electron transport chain. This results in decreased cellular respiration and an enzyme catalyzing the rate-limiting step of serine de novo synthesis, making SF3B1 mutant cells sensitive to serine starvation. As serine is a nonessential amino acid, healthy cells stay unaffected, indicating that depravation of serine might be a promising therapeutic strategy for SF3B1 mutant cancers.
W. Brian Dalton, Eric Helmenstine, Noel Walsh, Lukasz P. Gondek, Dhanashree S. Kelkar, Abigail Read, Rachael Natrajan, Eric S. Christenson, Barbara Roman, Samarjit Das, Liang Zhao, Robert D. Leone, Daniel Shinn, Taylor Groginski, Anil K. Madugundu, Arun Patil, Daniel J. Zabransky, Arielle Medford, Justin Lee, Alex J. Cole, Marc Rosen, Maya Thakar, Alexander Ambinder, Joshua Donaldson, Amy E. DeZern, Karen Cravero, David Chu, Rafael Madero-Marroquin, Akhilesh Pandey, Paula J. Hurley, Josh Lauring, Ben Park
BACK to Oncology