Potential Research Questions

Which treatment might improve outcome in HFpEF?
Which lifestyle intervention or medication can effectively reduce cardiovascular risk?
Can we stratify patients at risk to find out who needs tight monitoring or more aggressive treatment?
Can cardiovascular risk of medication be predicted?

Status Quo and Medical Need

Cardiovascular disease remains the leading single cause of death in large parts of the industrialized world. However, in some cardiovascular diseases, little progress has been made over the last couple years. Heart failure with preserved ejection fraction (HFpEF) is such an area, where unlike in HFrEF (Heart failure with reduced ejection fraction) current treatments show little effect.

Metabolic phenotyping technology from Biocrates has been helping to improve our understanding of metabolic factors contributing to cardiovascular morbidity and mortality. Among a wide range of research endeavours using Biocrates’ technology, Biocrates has teamed up with leading European institutes in the EU funded SysVasc and BiomarCARE projects.

Relevant Metabolite Classes

Amino acids and biogenic amines:

  • Multiple amino acid metabolites have been suggested as predictors of outcome in heart failure
  • Amino acid metabolism, especially arginine, is associated with myocardial infarction risk

Phospho- and sphingolipids:

  • LDL effect of metformin occurs through changes in phospholipid metabolism
  • Changes in lipid metabolism reported for genes associated with cardiovascular outcomes

Steroid hormones:

  • Involved in regulating glucose metabolism and blood pressure

Fatty acids:

  • Complex relationship between fatty acids and cardiovascular health (protective or damaging effects depending on structure and intake)
  • High free fatty acids may play an important role in atherosclerosis and cardiovascular events


  • Responsible for most detrimental effects of altered cholesterol metabolism?

Selected Publications

For more information, please contact us!

 For Research Use Only. Not for use in diagnostic procedures.

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