Scientific Publications 2015
Abuja, P. M.; Ehrhart, F.; Schoen, U.; et al.
Alterations in Human Liver Metabolome during Prolonged Cryostorage.
J. Proteome Res. 14 (7), p 2758–2768. doi: 10.1021/acs.jproteome.5b00025.
Allam-Ndoul, B.; Guénard, F.; Garneau, V.; et al.
Associations between branched chain amino acid levels, obesity and cardiometabolic complications
Integr Obesity Diabetes 1 (6). doi: 10.15761/IOD.1000134
Anton, G.; Wilson, R.; Yu, Z.; et al.
Pre-analytical sample quality: metabolite ratios as an intrinsic marker for prolonged room temperature exposure of serum samples
Plos One 2015. doi: 10.1371/journal.pone.0121495
Antonissen, G.; Croubels, S.; Pasmans, F.; et al.
Fumonisins affect the intestinal microbial homeostasis in broiler chickens, predisposing to necrotic enteritis
Veterinary research (46) 2015. doi: 10.1186/s13567-015-0234-8
Aumailley, L.; Dubois, M. J.; Garand, C.l; et al.
Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.
Experimental gerontology 72, p 192–203. doi: 10.1016/j.exger.2015.10.012.
Aumailley, L.; Garand, C.; Dubois, M. J.; et al.
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
PLoS ONE 10 (10), p e0140292. doi: 10.1371/journal.pone.0140292.
Barrios, C.; Spector, T. D.; Menni, C.
Blood, urine and faecal metabolite profiles in the study of adult renal disease
Archives of biochemistry and biophysics 2015. doi: 10.1016/j.abb.2015.10.006
Bonhoure, N.; Byrnes, A.; Moir, R. D.; et al.
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance
Genes & Dev. 2015. 29: 934-947. doi: 10.1101/gad.258350.115
Boroughs, L. K.; DeBerardinis, R. J.
Metabolic pathways promoting cancer cell survival and growth.
Nature cell biology 17 (4), p 351–359. doi: 10.1038/ncb3124.
Breit, M.; Weinberger, K. M.
Metabolic biomarkers for chronic kidney disease
Archives of biochemistry and biophysics 2015. doi: 10.1016/j.abb.2015.07.018
Breit, M.; Netzer, M.; Weinberger, K. M.; et al.
Modeling and Classification of Kinetic Patterns of Dynamic Metabolic Biomarkers in Physical Activity
PLoS computational biology (11) 2015.
Buttler, R. M.; Martens, F.; Fanelli, F.; et al.
Comparison of 7 Published LC-MS/MS Methods for the Simultaneous Measurement of Testosterone, Androstenedione, and Dehydroepiandrosterone in Serum
Clinical chemistry 2015. doi: 10.1373/clinchem.2015.242859
Cajka, T.; Fiehn, O.
Towards merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics.
Anal. Chem. doi: 10.1021/acs.analchem.5b04491.
Camillo, J.; Victorino, A. B.; Melo, A. A. de; et al.
Non-invasive prediction of embryo developmental potential by embryo culture medium quantitative secretomic
Fertility and Sterility (104) 2015.
Carayol, M.; Licaj, I.; Achaintre, D.; et al.
Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC
PLoS ONE (10) 2015. doi: 10.1371/journal.pone.0135437
Cermenati, G.; Audano, M.; Giatti, S.; et al.
Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy
Cell metabolism 2015. doi: 10.1016/j.cmet.2015.02.016
Cheng, M.; Wang, Ch.; Shiao, M.; et al.
Metabolic Disturbances Identified in Plasma Are Associated With Outcomes in Patients With Heart Failure: Diagnostic and Prognostic Value of Metabolomics
Journal of the American College of Cardiology 2015. doi: 10.1016/j.jacc.2015.02.018
Conlon, T. M.; Bartel, J.; Ballweg, K.; et al.
Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema.
Clinical science (London, England : 1979). doi: 10.1042/CS20150438.
da Costa, J. P.; Rocha-Santos, T.; Duarte, A. C.
Analytical tools to human assess aging. The rise of geri-omics.
TrAC Trends in Analytical Chemistry. doi: 10.1016/j.trac.2015.09.011.
Dale, I.; Roscher, A.; Lopes Carvalho, A.; et al.
Metabolic signature predicts progression and response after taxane-anthracycline neoadjuvant regimen
The Breast 2015.
Dale, I.; Roscher, A.; Fiegel, H.; et al.
New circulating lipid markers related to breast cancer
The Breast 2015.
Dame, Z. T.; Aziat, F.; Mandal, R.; et al.
The human saliva metabolome
Metabolomics 11 (6) 2015.
Daskalaki, E.; Easton, C.; G. Watson, D.
The Application of Metabolomic Profiling to the Effects of Physical Activity.
CMB 2 (4), p 233–263. doi: 10.2174/2213235X03666150211000831.
Denihan, N. M.; Walsh, B. H.; Reinke, S. N.; et al.
The effect of haemolysis on the metabolomic profile of umbilical cord blood.
Clinical biochemistry. doi: 10.1016/j.clinbiochem.2015.02.004.
Deschamps, C. L.; Connors, K. E.; Klein, M. S.; et al.
The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults.
PLoS ONE 10 (6), p e0130644. doi: 10.1371/journal.pone.0130644.
Di Gangi, I. M.; Mazza, T.; Fontana, A.; et al.
Metabolomic profile in pancreatic cancer patients: a consensusbased approach to identify highly discriminating metabolites
Oncotarget 2015. doi: 10.18632/oncotarget.6808
Draisma, H. H. M.; Pool, R.; Kobl, M.; et al.
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
Nat Commun 6, p 7208. doi: 10.1038/ncomms8208.
Ellis, B.; Hye, A.; Snowden, S. G.
Metabolic Modifications in Human Biofluids Suggest the Involvement of Sphingolipid, Antioxidant, and Glutamate Metabolism in Alzheimer's Disease Pathogenesis.
Journal of Alzheimer's disease : JAD. doi: 10.3233/JAD-141899.
Fattuoni, C.; Palmas, F.; Noto, A.; et al.
Perinatal Asphyxia: A Review from a Metabolomics Perspective
Molecules 2015. doi: 10.3390/molecules20047000
Fiandaca, M. S.; Zhong, X.; Cheema, A. K.; et al.
Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease.
Frontiers in neurology 6, p 237. doi: 10.3389/fneur.2015.00237.
Geurts, L.; Everard, A.; Van Hul, M.; et al.
Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota
Nat Commun 2015. doi: 10.1038/ncomms7495
Giskeødegård, G. F.; Hansen, A. F.; Bertilsson, H.; et al.
Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia.
British journal of cancer. doi: 10.1038/bjc.2015.411.
Glossmann
Alzheimer´s Disease May be Predicted by a Panel of Plasma Lipids. Do Bile Acids also Play a Role?
Glossmann
Bile Acids and Fibroblast Growth Factor 19 (FGF19). Is there a Connection to Cancer?
Glossmann
Getting high with Bile Acids? Bile Acids control Endocannabinoid Formation.
Glossmann
Metabolic Syndrome, Obesity, Insulin Resistance, Type 2 Diabetes and Bile Acids.
Glossmann
Power unseen: The Bile Acid Metabolome.
Glossmann
The Bile Acid Metabolome in Humans and Rodents.
González-Beltrán, A.; Li, P.; Zhao, J.; et al.
From Peer-Reviewed to Peer-Reproduced in Scholarly Publishing: The Complementary Roles of Data Models and Workflows in Bioinformatics.
PLoS ONE 10 (7), p e0127612. doi: 10.1371/journal.pone.0127612.
Greaves, R. F.; Pitkin, J.; Ho, C. S.; et al.
Hormone Modelling in Preterm Neonates: Establishment of Pituitary and Steroid Hormone Reference Intervals
The Journal of clinical endocrinology and metabolism 2015, jc20143681. doi: 10.1210/jc.2014-3681
Hagel, J. M.; Mandal, R.; Han, B.; et al.
Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants
BMC plant biology (15) 2015.
Halama, A.; Horsch, M.; Kastenmüller, G.; et al.
Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis
Archives of biochemistry and biophysics 2015.
Harrison, A.; Dubois, L. G.; St John-Williams, L.; et al.
Comprehensive proteomic and metabolomic signatures of nontypeable Haemophilus influenzae-induced acute otitis media reveal bacterial aerobic respiration in an immunosuppressed environment
Mol. Cell Proteomics 2015.
Hellmuth, C.; Kirchberg, F. F.; Lass, N.; et al.
Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children.
Journal of Diabetes Research.
Herberth, G.; Offenberg, K.; Rolle-Kampczyk, U.; et al.
Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases
American Academy of Allergy, Asthma & Immunology 2015. doi: 10.1016/j.jaci.2015.01.022
Holz, O.; Roepcke, S.; Watz, H.; et al.
Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD
Int J Chron Obstruct Pulmon Dis. (10) 2015. doi: 10.2147/COPD.S83269
Hounoum, B. M.; Blasco, H.; Emond, P.; et al.
Liquid chromatography-high resolution mass spectrometry-based cell metabolomics
TrAC Trends in Analytical Chemistry 2015. doi: 10.1016/j.trac.2015.08.003
Jeanneret, F.; Tonoli, D.; Rossier, M.; et al.
Evaluation of steroidomics by liquid chromatography hyphenated to mass spectrometry as a powerful analytical strategy for measuring human steroid perturbations
J Chromatogr A 2015. doi: 10.1016/j.chroma.2015.07.008
Kahle, M.; Schäfer, A.; Seelig, A.; et al.
High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice.
Molecular metabolism, 39–50. doi: 25685688.
Kastenmüller, G.; Raffler, J.; Gieger, C.; et al.
Genetics of human metabolism: an update.
Hum. Mol. Genet. doi: 10.1093/hmg/ddv263.
Kiermayer, C.; Northrup, E.; Schrewe, A.; et al.
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
Journal of the American Heart Association 4 (7). doi: 10.1161/JAHA.115.002153.
Klavins, K.; Koal, T.; Dallmann, G.; et al.
The ratio of phosphatidylcholines to lysophosphatidylcholines in plasma differentiates healthy controls from patients with Alzheimer's disease and mild cognitive impairment.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. doi: 10.1016/j.dadm.2015.05.003.
Klöting, N.; Hesselbarth, N.; Gericke, M.; et al.
Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites.
PLoS ONE 10 (12), S. e0143190. doi: 10.1371/journal.pone.0143190.
Köberlin, Marielle S.; Snijder, Berend; Heinz, Leonhard X.; et al.
A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses
Cell. 2015. doi: 10.1016/j.cell.2015.05.051
Lehmann, R.; Friedrich, T.; Krebiehl, G.; et al.
Metabolic Profiles during an Oral Glucose Tolerance Test in Pregnant Women with and without Gestational Diabetes
Experimental and clinical endocrinology & diabetes 123 (7) 2015. doi: 10.1055/s-0035-1549887
Liu, X.; Secombe, J.
The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif
Cell reports 13 (10), p 2219–2231. doi: 10.1016/j.celrep.2015.11.007
Liu, X.; Zheng, P.; Zhao, X.; et al.
Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry.
J. Proteome Res. doi: 10.1021/acs.jproteome.5b00144.
Meier, S. M.; M., B.; Ullmann, R.; et al.
Proteomic and Metabolomic Analyses Reveal Contrasting Anti-Inflammatory Effects of an Extract of Mucor Racemosus Secondary Metabolites Compared to Dexamethasone
PLoS ONE 10 (10) 2015. doi: 10.1371/journal.pone.0140367
Metzler-Zebeli, B. U.; Eberspächer, Eva; et al.
Enzymatically Modified Starch Ameliorates Postprandial Serum Triglycerides and Lipid Metabolome in Growing Pigs
PLoS ONE. doi: 10.1371/journal.pone.0130553
Metzler-Zebeli, B. U.; Ertl, R.; Klein, D.; et al.
Explorative study of metabolic adaptations to various dietary calcium intakes and cereal sources on serum metabolome and hepatic gene expression in juvenile pigs.
Metabolomics 11 (3), p 545–558. doi: 10.1007/s11306-014-0714-2.
Mook-Kanamori, Dennis O.; Mutsert, Renée de; Rensen, Patrick C N; et al.
Type 2 diabetes is associated with postprandial amino acid measures
Archives of biochemistry and biophysics 2015. doi: 10.1016/j.abb.2015.08.003
Morris, Ciara; O'Grada, Colm M.; Ryan, Miriam F.; et al.
Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study
Lipids in health and disease 14 (1) 2014.
Moser, V. C.; Stewart, N.; Freeborn, D. L.; et al.
Assessment of serum biomarkers in rats after exposure to pesticides of different chemical classes.
Toxicology and applied pharmacology 2015, 282 (2), 161–174. DOI: 10.1016/j.taap.2014.11.016.
Nahon, K. J.; Boon, M. R.; Bakker, L. E. H.; et al.
Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: a metabolomics study
Archives of biochemistry and biophysics 2015. doi: 10.1016/j.abb.2015.09.001
Ost, M.; Coleman, V.; Voigt, A.; et al.
Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action.
Molecular metabolism. doi: 10.1016/j.molmet.2015.11.002.
Pan, X.; Nasaruddin, M. L.; Elliott, C. T.; et al.
Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome.
Neurobiology of Aging. doi: 10.1016/j.neurobiolaging.2015.11.014.
Pena, Michelle J.; Zeeuw, Dick de; Mischak, Harald; et al.
Prognostic clinical and molecular biomarkers of renal disease in type 2 diabetes
Nephrol. Dial. Transplant. doi: 10.1093/ndt/gfv252
Puxbaum, V.; Mattanovich, D.; Gasser, B.
Quo vadis? The challenges of recombinant protein folding and secretion in Pichia pastoris.
Applied microbiology and biotechnology 99 (7), p 2925–2938. doi: 10.1007/s00253-015-6470-z.
Renner, S.; Blutke, A.; Streckel, E.; et al.
Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models.
The Journal of pathology. doi: 10.1002/path.4655.
Richter, Martin E.; Neugebauer, Sophie; Engelmann, Falco; et al.
Biomarker candidates for the detection of an infectious etiology of febrile neutropenia
Infection 2015. doi: 10.1007/s15010-015-0830-6
Ruiz, M.; Jove, M.; Schluter, A.; et al.
Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy
Hum. Mol. Genet. 2015. doi: 10.1093/hmg/ddv375
Rußmayer, H.; Buchetics, M.; Gruber, C.; et al.
Systems-level organization of yeast methylotrophic lifestyle
BMC biology (13) 2015. doi: 10.1186/s12915-015-0186-5
Salek, Reza M.; Arita, Masanori; Dayalan, Saravanan; et al.
Embedding standards in metabolomics: the Metabolomics Society data standards task group
Metabolomics 11 (4) 2015. doi: 10.1007/s11306-015-0821-8
Schmidt, J. A.; Rinaldi, S.; Scalbert, A.; et al.
Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort
Eur J Clin Nutr 2015. doi: 10.1038/ejcn.2015.144
Schmidt, J. A.; Rinaldi, S.; Ferrari, P.; et al.
Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort.
The American journal of clinical nutrition 102 (6), p 1518–1526. doi: 10.3945/ajcn.115.111989.
Shahzad, M. & Ullah, E.
Integrative 1H-NMR-based Metabolomic Profiling to Identify Type-2 Diabetes Biomarkers: An Application to a Population of Qatar
Metabolomics, Journal of Postgenomics Drug & Biomarker Development 2015. doi: 10.4172/2153-0769.1000136
Sirrs, S.; van Karnebeek, C. D. M.; Peng, X.; et al.
Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms.
Orphanet journal of rare diseases 10, p 38. doi: 10.1186/s13023-015-0248-3.
Stanley, J. L.; Sulek, K.; Andersson, I. J.; et al.
Sildenafil Therapy Normalizes the Aberrant Metabolomic Profile in the Comt(-/-) Mouse Model of Preeclampsia/Fetal Growth Restriction.
Scientific reports 5, p 18241. doi: 10.1038/srep18241.
Stepien, Magdalena; Duarte-Salles, Talita; Fedirko, Veronika; et al.
Alteration of Amino Acid and Biogenic Amine Metabolism in Hepatobiliary Cancers: Findings from a Prospective Cohort Study
International journal of cancer. Journal international du cancer 2015. doi: 10.1002/ijc.29718
Tautenhahn, H.; Brückner, S.; Baumann, S.; et al.
Attenuation of Postoperative Acute Liver Failure by Mesenchymal Stem Cell Treatment Due to Metabolic Implications
Annals of Surgery 2015. doi: 10.1097/SLA.0000000000001155.
Tsepilov, Y. A.; Shin, S.; Soranzo, N.; et al.
Non-Additive Effects of Genes in Human Metabolomics
Genetics 2015. doi: 10.1534/genetics.115.175760
Tsuprykov, O.; Chaykovska, L.; Kretschmer, A.; et al.
Endothelin-1 Overexpression Improves Renal Function in eNOS Knockout Mice.
Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology 37 (4), p 1474–1490. doi: 10.1159/000438516.
Van den Berg, R.; Mook-Kanamori, D. O.; Donga, E.; et al.
A single night of sleep curtailment increases plasma acylcarnitines: novel insights in the relationship between sleep and insulin resistance
Archives of biochemistry and biophysics 2015. doi: 10.1016/j.abb.2015.09.017
Vehmas, A. P.; Adam, M.; Laajala, T. D.; et al.
Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse.
Journal of Proteomics. doi: 10.1016/j.jprot.2015.12.009.
Wang, Thomas J.; Gupta, Deepak K.
Metabolite profiles in heart failure: looking for unique signatures in a heterogeneous syndrome
Journal of the American College of Cardiology (65) 2015. doi: 10.1016/j.jacc.2015.02.019
Wang, Z.; Faddaoui, A.; Bachvarova, M.; et al.
BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.
Oncotarget 6 (31), p 31522–31543. doi: 10.18632/oncotarget.5159.
Widmann, P.; Reverter, A.; Weikard, R.; et al.
Systems biology analysis merging phenotype, metabolomic and genomic data identifies Non-SMC Condensin I Complex, Subunit G (NCAPG) and cellular maintenance processes as major contributors to genetic variability in bovine feed efficiency.
PLoS ONE 10 (4), p e0124574. doi: 10.1371/journal.pone.0124574.
Wittenbecher, C.; Mühlenbruch, K.; Kröger J.; et al.
Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes
Am J Clin Nutr doi: 10.3945/ajcn.114.099150.
Xu, T.; Brandmaier, S.; Messias, A. C.; et al.
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes
Diabetes Care 38 (10) 2015. doi: 10.2337/dc15-0658
Zhang, W.; Likhodii, S.; Aref-Eshghi, E.; et al.
Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis
The Journal of Rheumatology 2015. doi: 10.3899/jrheum.141252
Zhang, W.; Sun, G.; Likhodii, S.; et al.
Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2015. doi: 10.1016/j.joca.2015.12.004
Zhou, K.; Xie, G.; Wang, J.; et al.
Metabonomics Reveals Metabolite Changes in Biliary Atresia Infants.
J. Proteome Res. 2015. doi: 10.1021/acs.jproteome.5b00125.
Zordoky, B. N.; Sung, M. M.; Ezekowitz, J.; et al.
Metabolomic fingerprint of heart failure with preserved ejection fraction.
PLoS ONE 10 (5), p e0124844. doi: 10.1371/journal.pone.0124844.
Zwadlo, C.; Schmidtmann, E.; Szaroszyk, M.; et al.
Antiandrogenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction
Circulation 131 (12), p 1071-1081. doi: 10.1161/CIRCULATIONAHA.114.012066